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Para-Aortic Lymph Node Micrometastasis in Patients with Node-Negative Biliary Cancer

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Title: Para-Aortic Lymph Node Micrometastasis in Patients with Node-Negative Biliary Cancer
Authors: Yonemori, Atsuya Browse this author
Kondo, Satoshi Browse this author
Matsuno, Yoshihiro Browse this author
Ito, Tomoo Browse this author
Tanaka, Eiichi Browse this author
Hirano, Satoshi Browse this author →KAKEN DB
Keywords: Para-aortic lymph node
Isolated tumor cells
Biliary cancer
Issue Date: Oct-2011
Publisher: Karger
Journal Title: Digestive Surgery
Volume: 28
Issue: 4
Start Page: 315
End Page: 321
Publisher DOI: 10.1159/000330784
PMID: 21921633
Abstract: Background/Aims: The presence of para-aortic lymph node metastasis in biliary cancer negatively impacts prognosis. The present study aims to immunohistochemically identify and evaluate the clinical significance of para-aortic lymph node micrometastases in 66 patients who had undergone curative resection of biliary cancer. Methods: We used an antibody against cytokeratins 7 and 8 (CAM5.2) to immunostain 529 para-aortic lymph nodes that were negative according to conventional analysis from 66 patients with biliary cancer. Results: We detected CAM5.2-positive occult carcinoma cells in para-aortic lymph nodes from 3 (5%) of the 66 patients and in 3 (0.6%) of the 529 para-aortic lymph nodes. One of the three patients also had micrometastasis in the regional lymph nodes. All three patients with para-aortic lymph node micrometastasis are alive at 45, 48 and 90 months after surgery despite having locally advanced cancer. Conclusions: Occult cancer cells were identified in para-aortic lymph nodes from 5% of patients with node-negative biliary cancer, yet these patients have survived over the long term. The presence of para-aortic nodal micrometastasis might not have influence on survival. However, further studies including a greater number of patients are required to support this notion.
Rights: © 2011 S. Karger AG, Basel
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 平野 聡

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