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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Para-Aortic Lymph Node Micrometastasis in Patients with Node-Negative Biliary Cancer
| Title: | Para-Aortic Lymph Node Micrometastasis in Patients with Node-Negative Biliary Cancer |
| Authors: | Yonemori, Atsuya Browse this author | | Kondo, Satoshi Browse this author | | Matsuno, Yoshihiro Browse this author | | Ito, Tomoo Browse this author | | Tanaka, Eiichi Browse this author | | Hirano, Satoshi Browse this author →KAKEN DB |
| Keywords: | Para-aortic lymph node | | Micrometastasis | | Isolated tumor cells | | Biliary cancer |
| Issue Date: | Oct-2011 |
| Publisher: | Karger |
| Journal Title: | Digestive Surgery |
| Volume: | 28 |
| Issue: | 4 |
| Start Page: | 315 |
| End Page: | 321 |
| Publisher DOI: | 10.1159/000330784 |
| PMID: | 21921633 |
| Abstract: | Background/Aims: The presence of para-aortic lymph node metastasis in biliary cancer negatively impacts prognosis. The present study aims to immunohistochemically identify and evaluate the clinical significance of para-aortic lymph node micrometastases in 66 patients who had undergone curative resection of biliary cancer. Methods: We used an antibody against cytokeratins 7 and 8 (CAM5.2) to immunostain 529 para-aortic lymph nodes that were negative according to conventional analysis from 66 patients with biliary cancer. Results: We detected CAM5.2-positive occult carcinoma cells in para-aortic lymph nodes from 3 (5%) of the 66 patients and in 3 (0.6%) of the 529 para-aortic lymph nodes. One of the three patients also had micrometastasis in the regional lymph nodes. All three patients with para-aortic lymph node micrometastasis are alive at 45, 48 and 90 months after surgery despite having locally advanced cancer. Conclusions: Occult cancer cells were identified in para-aortic lymph nodes from 5% of patients with node-negative biliary cancer, yet these patients have survived over the long term. The presence of para-aortic nodal micrometastasis might not have influence on survival. However, further studies including a greater number of patients are required to support this notion. |
| Rights: | © 2011 S. Karger AG, Basel |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/47664 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 平野 聡
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