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Possible involvement of uncoupling protein 1 in appetite control by leptin

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Title: Possible involvement of uncoupling protein 1 in appetite control by leptin
Authors: Okamatsu-Ogura, Yuko Browse this author →KAKEN DB
Nio-Kobayashi, Junko Browse this author →KAKEN DB
Iwanaga, Toshihiko Browse this author →KAKEN DB
Terao, Akira Browse this author →KAKEN DB
Kimura, Kazuhiro Browse this author →KAKEN DB
Saito, Masayuki Browse this author
Keywords: uncoupling protein 1
brown adipose tissue
leptin
appetite control
Issue Date: Nov-2011
Publisher: Royal Society of Medicine Press
Journal Title: Experimental Biology and Medicine
Volume: 236
Issue: 11
Start Page: 1274
End Page: 1281
Publisher DOI: 10.1258/ebm.2011.011143
PMID: 21987829
Abstract: Leptin reduces body fat by decreasing food intake and increasing energy expenditure. Uncoupling protein (UCP) 1, a key molecule for brown adipose tissue (BAT) thermogenesis, was reported to contribute to the stimulatory effect of leptin on energy expenditure. To clarify whether UCP1 is also involved in the anorexigenic effect of leptin, in this study we examined the effect of leptin on food intake using wild-type (WT) and UCP1-deficient (UCP1-KO) mice. Repeated injection of leptin decreased food intake more markedly in WT mice than in UCP1-KO mice, while a single injection of leptin showed similar effects in the two groups of mice. As chronic leptin stimulation induces UCP1 expression in BAT and ectopically in white adipose tissue (WAT), we mimicked the UCP1 induction by repeated injection of CL316,243 (CL), a highly specific β3-adrenoceptor agonist, and measured food intake in response to a single injection of leptin. Two-week treatment with CL enhanced the anorexigenic effect of leptin in WT mice, but not in UCP1-KO mice. Three-day treatment with CL in WT mice also enhanced the anorexigenic effect of leptin and leptin-induced phosphorylation of STAT3 in the arcuate nucleus of the hypothalamus, without any notable change in adiposity. These results indicate that UCP1 enhances leptin action at the hypothalamus level, suggesting UCP1 contributes to the control of energy balance not only through the regulation of energy expenditure but also through appetite control by modulating leptin action.
Rights: Exp Biol Med November 2011 vol. 236 no. 11 1274-1281, doi: 10.1258/ebm.2011.011143. This is the final draft, after peer-review, of a manuscript published in RSM journals: www.rsmpress.com.
Type: article (author version)
URI: http://hdl.handle.net/2115/47824
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岡松 優子

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