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Phase I study of concurrent real-time tumor-tracking thoracic radiation therapy with paclitaxel and carboplatin in locally advanced non-small cell lung cancer
Title: | Phase I study of concurrent real-time tumor-tracking thoracic radiation therapy with paclitaxel and carboplatin in locally advanced non-small cell lung cancer |
Authors: | Sakakibara-Konishi, Jun Browse this author →KAKEN DB | Oizumi, Satoshi Browse this author →KAKEN DB | Kinoshita, Ichiro Browse this author →KAKEN DB | Shinagawa, Naofumi Browse this author →KAKEN DB | Kikuchi, Junko Browse this author | Kato, Mototsugu Browse this author →KAKEN DB | Inoue, Tetsuya Browse this author →KAKEN DB | Katoh, Norio Browse this author →KAKEN DB | Onimaru, Rikiya Browse this author →KAKEN DB | Shirato, Hiroki Browse this author →KAKEN DB | Dosaka-Akita, Hirotoshi Browse this author →KAKEN DB | Nishimura, Masaharu Browse this author →KAKEN DB |
Keywords: | Phase I study | Non-small cell lung cancer | Chemotherapy | Paclitaxel | Carboplatin | Radiation |
Issue Date: | Nov-2011 |
Publisher: | Elsevier Ireland |
Journal Title: | Lung Cancer |
Volume: | 74 |
Issue: | 2 |
Start Page: | 248 |
End Page: | 252 |
Publisher DOI: | 10.1016/j.lungcan.2011.02.009 |
PMID: | 21397973 |
Abstract: | Introduction: Although paclitaxel with carboplatin and thoracic radiotherapy has improved survival for patients with locally advanced unresectable non-small cell lung cancer (NSCLC), the optimal dose of paclitaxel has not been well defined in Japan. This study was conducted to determine the maximum tolerated dose (MTD) and recommended dose (RD) of paclitaxel in combination with carboplatin and concurrent real-time tumor-tracking thoracic radiation therapy (thoracic RTRT). Patients and methods: Previously untreated patients with histologically confirmed, locally advanced unresectable NSCLC were eligible. Before treatment, gold markers were inserted into the lung and the mediastinum of all patients. RTRT comprised a total of 66 Gy at 2 Gy/fraction, 5 days/week, for 7 weeks. Patients received paclitaxel at a starting dose of 40 mg/m2 followed by carboplatin at a fixed area under the curve (AUC) of 2, as a weekly regimen with RTRT. The dose of paclitaxel was escalated by 5 mg/m2 per level. Results: Eight patients with locally advanced unresectable NSCLC were enrolled and treated with two dose levels of paclitaxel (40 mg/m2 and 45 mg/m2), carboplatin (AUC = 2) and RTRT. No dose limiting toxicities (DLTs) were observed at Level 1 (paclitaxel, 40 mg/m2 and carboplatin, AUC = 2). At Level 2 (paclitaxel, 45 mg/m2 and carboplatin, AUC = 2), two of five patients experienced DLTs, in the form of esophagitis and discontinuation of chemotherapy more than twice. The MTD and RD of paclitaxel were thus defined as 45 mg/m2 and 40 mg/m2, respectively. Conclusions: This phase I study was well tolerated and the RD of paclitaxel and carboplatin with RTRT is 40 mg/m2 at AUC = 2, respectively. Further studies are warranted to evaluate the efficacy of this regimen. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/47868 |
Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 大泉 聡史
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