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Viral-mediated stabilization of AU-rich element containing mRNA contributes to cell transformation

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Title: Viral-mediated stabilization of AU-rich element containing mRNA contributes to cell transformation
Authors: Kuroshima, Takeshi Browse this author
Aoyagi, Mariko Browse this author
Yasuda, Motoaki Browse this author
Kitamura, Tetsuya Browse this author
Jehung, Jumond P. Browse this author
Ishikawa, Makoto Browse this author
Kitagawa, Yoshimasa Browse this author
Totsuka, Yasunori Browse this author
Shindoh, Masanobu Browse this author
Higashino, Fumihiro Browse this author →KAKEN DB
Keywords: adenovirus
AU-rich element
Issue Date: 30-Jun-2011
Publisher: Nature Publishing Group
Journal Title: Oncogene
Volume: 30
Issue: 26
Start Page: 2912
End Page: 2920
Publisher DOI: 10.1038/onc.2011.14
PMID: 21317928
Abstract: E4orf6 is one of the oncogene products of adenovirus and it also plays an important role for transportation of cellular and viral mRNA during the late phase of virus infection. We previously revealed that E4orf6 controls the fate of AU-rich element (ARE) containing mRNA by perturbing the CRM1-dependent export mechanism. Here, we show that E4orf6 stabilizes ARE-mRNA through the region required for its oncogenic activity and ubiquitin E3 ligase assembly. Cells that failed to stabilize ARE-mRNA after HuR knockdown were unable to produce colonies in soft-agar, even when E4orf6 was expressed. Furthermore, the stabilized ARE-mRNA induced the transformation of rodent immortalized cells. These findings indicate that stabilized ARE-mRNA is necessary, if not all, for the oncogenic activity of E4orf6 and has the potential to transform cells at least under a certain condition.
Type: article (author version)
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 東野 史裕

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