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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >
Viral-mediated stabilization of AU-rich element containing mRNA contributes to cell transformation
| Title: | Viral-mediated stabilization of AU-rich element containing mRNA contributes to cell transformation |
| Authors: | Kuroshima, Takeshi Browse this author | | Aoyagi, Mariko Browse this author | | Yasuda, Motoaki Browse this author | | Kitamura, Tetsuya Browse this author | | Jehung, Jumond P. Browse this author | | Ishikawa, Makoto Browse this author | | Kitagawa, Yoshimasa Browse this author | | Totsuka, Yasunori Browse this author | | Shindoh, Masanobu Browse this author | | Higashino, Fumihiro Browse this author →KAKEN DB |
| Keywords: | adenovirus | | AU-rich element | | E4orf6 | | transformation | | stabilization |
| Issue Date: | 30-Jun-2011 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Oncogene |
| Volume: | 30 |
| Issue: | 26 |
| Start Page: | 2912 |
| End Page: | 2920 |
| Publisher DOI: | 10.1038/onc.2011.14 |
| PMID: | 21317928 |
| Abstract: | E4orf6 is one of the oncogene products of adenovirus and it also plays an important role for transportation of cellular and viral mRNA during the late phase of virus infection. We previously revealed that E4orf6 controls the fate of AU-rich element (ARE) containing mRNA by perturbing the CRM1-dependent export mechanism. Here, we show that E4orf6 stabilizes ARE-mRNA through the region required for its oncogenic activity and ubiquitin E3 ligase assembly. Cells that failed to stabilize ARE-mRNA after HuR knockdown were unable to produce colonies in soft-agar, even when E4orf6 was expressed. Furthermore, the stabilized ARE-mRNA induced the transformation of rodent immortalized cells. These findings indicate that stabilized ARE-mRNA is necessary, if not all, for the oncogenic activity of E4orf6 and has the potential to transform cells at least under a certain condition. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/47941 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 東野 史裕
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