| Title: | Regional partition coefficient of water in patients with cerebrovascular disease and its effect on rCBF assessment |
| Authors: | Hirata, Kenji Browse this author →KAKEN DB |
| Hattori, Naoya Browse this author |
| Katoh, Chietsugu Browse this author |
| Shiga, Tohru Browse this author |
| Kuroda, Satoshi Browse this author |
| Kubo, Naoki Browse this author |
| Usui, Reiko Browse this author |
| Kuge, Yuji Browse this author |
| Tamaki, Nagara Browse this author |
| Keywords: | brain-blood partition coefficient of water |
| cerebral blood flow |
| cerebrovascular disease |
| compartmental model |
| 15O positron emission tomography |
| Issue Date: | Jan-2011 |
| Publisher: | Lippincott Williams & Wilkins |
| Journal Title: | Nuclear Medicine Communications |
| Volume: | 32 |
| Issue: | 1 |
| Start Page: | 63 |
| End Page: | 70 |
| Publisher DOI: | 10.1097/MNM.0b013e3283412106 |
| PMID: | 21076345 |
| Abstract: | Objective: Cerebral blood flow (CBF) estimation with C15O2 PET usually assumes a single tissue compartment model and a fixed brain-blood partition coefficient of water. However, the partition coefficient may change in pathological conditions. The purpose of this study was to investigate the changes of partition coefficient of water in pathological regions and its effect on regional CBF assessment. Methods: Study protocol included 22 patients with occlusive cerebrovascular disease to compare partition coefficients among 3 regions (infarction, non-infarct hypoperfusion, and contralateral) in the pathologic brain (analysis A), and to compare CBF estimated using fixed partition coefficient (CBF fixed) and CBF estimated using floating partition coefficients (CBF float)(analysis B). Results: Partition coefficient in the infarction (0.55 ± 0.07 ml/g) was lower than that in contralateral normal cortex (0.68 ± 0.05 ml/g), whereas non-infarct hypoperfusion did not show a significant change (0.67 ± 0.06 ml/g). As a result, use of a fixed partition coefficient of normal volunteers (0.70 ml/g) resulted in an underestimation in rCBF by 12% in infarction area (P<0.05), while estimation errors were smaller and induced no significant difference in non-infarct hypoperfusion area or in contralateral areas. Conclusions: Partition coefficient is stable except for the infarction, and CBF estimation using a fixed partition coefficient of normal volunteers provides clinically appreciable information in patients with cerebrovascular disease. |
| Rights: | This is a non-final version of an article published in final form in Nuclear Medicine Communications, Jan. 2011, 32(1), 63-70 |
| Relation: | http://journals.lww.com/nuclearmedicinecomm/pages/default.aspx |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/47945 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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