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Regional partition coefficient of water in patients with cerebrovascular disease and its effect on rCBF assessment

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Title: Regional partition coefficient of water in patients with cerebrovascular disease and its effect on rCBF assessment
Authors: Hirata, Kenji Browse this author →KAKEN DB
Hattori, Naoya Browse this author
Katoh, Chietsugu Browse this author
Shiga, Tohru Browse this author
Kuroda, Satoshi Browse this author
Kubo, Naoki Browse this author
Usui, Reiko Browse this author
Kuge, Yuji Browse this author
Tamaki, Nagara Browse this author
Keywords: brain-blood partition coefficient of water
cerebral blood flow
cerebrovascular disease
compartmental model
15O positron emission tomography
Issue Date: Jan-2011
Publisher: Lippincott Williams & Wilkins
Journal Title: Nuclear Medicine Communications
Volume: 32
Issue: 1
Start Page: 63
End Page: 70
Publisher DOI: 10.1097/MNM.0b013e3283412106
PMID: 21076345
Abstract: Objective: Cerebral blood flow (CBF) estimation with C15O2 PET usually assumes a single tissue compartment model and a fixed brain-blood partition coefficient of water. However, the partition coefficient may change in pathological conditions. The purpose of this study was to investigate the changes of partition coefficient of water in pathological regions and its effect on regional CBF assessment. Methods: Study protocol included 22 patients with occlusive cerebrovascular disease to compare partition coefficients among 3 regions (infarction, non-infarct hypoperfusion, and contralateral) in the pathologic brain (analysis A), and to compare CBF estimated using fixed partition coefficient (CBF fixed) and CBF estimated using floating partition coefficients (CBF float)(analysis B). Results: Partition coefficient in the infarction (0.55 ± 0.07 ml/g) was lower than that in contralateral normal cortex (0.68 ± 0.05 ml/g), whereas non-infarct hypoperfusion did not show a significant change (0.67 ± 0.06 ml/g). As a result, use of a fixed partition coefficient of normal volunteers (0.70 ml/g) resulted in an underestimation in rCBF by 12% in infarction area (P<0.05), while estimation errors were smaller and induced no significant difference in non-infarct hypoperfusion area or in contralateral areas. Conclusions: Partition coefficient is stable except for the infarction, and CBF estimation using a fixed partition coefficient of normal volunteers provides clinically appreciable information in patients with cerebrovascular disease.
Rights: This is a non-final version of an article published in final form in Nuclear Medicine Communications, Jan. 2011, 32(1), 63-70
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 平田 健司

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