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Interactions between canine RAD51 and full length or truncated BRCA2 BRC repeats

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Title: Interactions between canine RAD51 and full length or truncated BRCA2 BRC repeats
Authors: Ochiai, K. Browse this author
Yoshikawa, Y. Browse this author
Oonuma, T. Browse this author
Tomioka, Y. Browse this author
Hashizume, K. Browse this author
Morimatsu, M. Browse this author
Keywords: Canine
Issue Date: Nov-2011
Publisher: Elsevier
Journal Title: The Veterinary Journal
Volume: 190
Issue: 2
Start Page: 293
End Page: 295
Publisher DOI: 10.1016/j.tvjl.2010.11.001
Abstract: In humans, mutations of the breast cancer susceptibility protein BRCA2 interact with recombinase RAD51 and increase the risk of cancer. This interaction occurs via a series of eight BRC repeat sequences in BRCA2. A mammalian two-hybrid assay using individual BRC repeats demonstrated that all the repeats except BRC6 bind RAD51 strongly (BRC1, 2 and 4), with intermediate strength (BRC8), or weakly (BRC3, 5 and 7). In serial deletion mutation experiments, the binding strengths were increased when the C-terminal BRC repeat was removed from BRC1-8, BRC1-5 and BRC1-3. These results provide an understanding of the basic function of canine BRCA2 and may be helpful to estimate the effect of missense or truncation mutations in canine mammary tumours.
Type: article (author version)
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 森松 正美

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