HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Impact of residual in situ carcinoma on postoperative survival in 125 patients with extrahepatic bile duct carcinoma

Files in This Item:
JHBPS17-2_166-173.pdf197.97 kBPDFView/Open
Please use this identifier to cite or link to this item:

Title: Impact of residual in situ carcinoma on postoperative survival in 125 patients with extrahepatic bile duct carcinoma
Authors: Nakanishi, Yoshitsugu Browse this author
Kondo, Satoshi Browse this author →KAKEN DB
Zen, Yoh Browse this author →KAKEN DB
Yonemori, Atsuya Browse this author
Kubota, Kanako Browse this author
Kawakami, Hiroshi Browse this author →KAKEN DB
Tanaka, Eiichi Browse this author →KAKEN DB
Hirano, Satoshi Browse this author →KAKEN DB
Itoh, Tomoo Browse this author →KAKEN DB
Nakanuma, Yasuni Browse this author →KAKEN DB
Keywords: carcinoma in situ
superficial spread
extrahepatic bile duct carcinoma
Issue Date: Mar-2010
Publisher: Springer Japan
Journal Title: Journal of Hepato-Biliary-Pancreatic Sciences
Volume: 17
Issue: 2
Start Page: 166
End Page: 173
Publisher DOI: 10.1007/s00534-009-0127-1
PMID: 19521656
Abstract: Purpose: The aim of this study was to determine the impact of the presence of carcinoma in situ at the bile duct stump on postoperative survival in patients who underwent resection of extrahepatic bile duct carcinoma. Methods: The patients with resected extrahepatic bile duct carcinoma were divided into three groups according to resected margin status: no evidence of residual carcinoma (Negative group, n=96); carcinoma in situ at the bile duct stump (CIS group, n=10); and invasive carcinoma at any surgical margin (Invasive group, n=19). Cause-specific survival for these groups was compared statistically. Results: Surgical margin status was identified as a prognostic factor on univariate analysis (p=0.005) and was an independent prognostic factor on multivariate analysis (p=0.018). The CIS group displayed significantly better survival than the Invasive group (p=0.006), and the survival was comparable to that for the Negative group (p=0.533). Two of three patients in the CIS group with local recurrence died >5 years after surgical resection. Conclusions: Patients with positive ductal margins of carcinoma in situ of the extrahepatic bile duct do not appear to show different survival after resection compared to patients with negative margins, but remnant carcinoma in situ is likely to develop late local recurrence.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 平野 聡

Export metadata:

OAI-PMH ( junii2 , jpcoar )


Feedback - Hokkaido University