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UNC93B1 Physically Associates with Human TLR8 and Regulates TLR8-Mediated Signaling

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/48290

Title: UNC93B1 Physically Associates with Human TLR8 and Regulates TLR8-Mediated Signaling
Authors: Itoh, Hiroki Browse this author
Tatematsu, Megumi Browse this author
Watanabe, Ayako Browse this author
Iwano, Katsunori Browse this author
Funami, Kenji Browse this author
Seya, Tsukasa Browse this author
Matsumoto, Misako Browse this author →KAKEN DB
Issue Date: 2-Dec-2011
Publisher: Public Library of Science
Journal Title: PLoS One
Volume: 6
Issue: 12
Start Page: e28500
Publisher DOI: 10.1371/journal.pone.0028500
Abstract: Toll-like receptors (TLRs) 3, 7, 8, and 9 are localized to intracellular compartments where they encounter foreign or self nucleic acids and activate innate and adaptive immune responses. The endoplasmic reticulum (ER)-resident membrane protein, UNC93B1, is essential for intracellular trafficking and endolysosomal targeting of TLR7 and TLR9. TLR8 is phylogenetically and structurally related to TLR7 and TLR9, but little is known about its localization or function. In this study, we demonstrate that TLR8 localized to the early endosome and the ER but not to the late endosome or lysosome in human monocytes and HeLa transfectants. UNC93B1 physically associated with human TLR8, similar to TLRs 3, 7, and 9, and played a critical role in TLR8-mediated signaling. Localization analyses of TLR8 tail-truncated mutants revealed that the transmembrane domain and the Toll/interleukin-1 receptor domain were required for proper targeting of TLR8 to the early endosome. Hence, although UNC93B1 participates in intracellular trafficking and signaling for all nucleotide-sensing TLRs, the mode of regulation of TLR localization differs for each TLR.
Rights: http://creativecommons.org/licenses/by/3.0/
Type: article
URI: http://hdl.handle.net/2115/48290
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松本 美佐子

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