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UNC93B1 Physically Associates with Human TLR8 and Regulates TLR8-Mediated Signaling

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この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/48290

タイトル: UNC93B1 Physically Associates with Human TLR8 and Regulates TLR8-Mediated Signaling
著者: Itoh, Hiroki 著作を一覧する
Tatematsu, Megumi 著作を一覧する
Watanabe, Ayako 著作を一覧する
Iwano, Katsunori 著作を一覧する
Funami, Kenji 著作を一覧する
Seya, Tsukasa 著作を一覧する
Matsumoto, Misako 著作を一覧する
発行日: 2011年12月 2日
出版者: Public Library of Science
誌名: PLoS One
巻: 6
号: 12
開始ページ: e28500
出版社 DOI: 10.1371/journal.pone.0028500
抄録: Toll-like receptors (TLRs) 3, 7, 8, and 9 are localized to intracellular compartments where they encounter foreign or self nucleic acids and activate innate and adaptive immune responses. The endoplasmic reticulum (ER)-resident membrane protein, UNC93B1, is essential for intracellular trafficking and endolysosomal targeting of TLR7 and TLR9. TLR8 is phylogenetically and structurally related to TLR7 and TLR9, but little is known about its localization or function. In this study, we demonstrate that TLR8 localized to the early endosome and the ER but not to the late endosome or lysosome in human monocytes and HeLa transfectants. UNC93B1 physically associated with human TLR8, similar to TLRs 3, 7, and 9, and played a critical role in TLR8-mediated signaling. Localization analyses of TLR8 tail-truncated mutants revealed that the transmembrane domain and the Toll/interleukin-1 receptor domain were required for proper targeting of TLR8 to the early endosome. Hence, although UNC93B1 participates in intracellular trafficking and signaling for all nucleotide-sensing TLRs, the mode of regulation of TLR localization differs for each TLR.
資料タイプ: article
URI: http://hdl.handle.net/2115/48290
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 松本 美佐子

 

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