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Thin films of single-walled carbon nanotubes promote human osteoblastic cells (Saos-2) proliferation in low serum concentrations

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Title: Thin films of single-walled carbon nanotubes promote human osteoblastic cells (Saos-2) proliferation in low serum concentrations
Authors: Akasaka, Tsukasa Browse this author →KAKEN DB
Yokoyama, Atsuro Browse this author
Matsuoka, Makoto Browse this author
Hashimoto, Takeshi Browse this author
Watari, Fumio Browse this author
Keywords: Carbon nanotubes
Thin film
Cell proliferation
Serum
Osteoblastic cells
Protein adsorption
Issue Date: Apr-2010
Publisher: Elsevier
Journal Title: Materials Science and Engineering: C
Volume: 30
Issue: 3
Start Page: 391
End Page: 399
Publisher DOI: 10.1016/j.msec.2009.12.006
Abstract: One strategy used for the regeneration of bone is the development of cell culture substrates and scaffolds that can control osteoblast proliferation and differentiation. In recent investigations, carbon nanotubes (CNTs) have been utilized as scaffolds for osteoblastic cell cultures; however, there are only a few reports describing the proliferation of osteoblastic cells on thin CNT films; in particular, the effects of serum concentration on cell proliferation has not been studied. In the present study, we prepared culture dishes with homogeneous thin or thick films of non-modified CNTs and examined the effect of serum concentrations on human osteoblastic cells (Saos-2) proliferation in these culture dishes. We demonstrated that the ratio of cell proliferation was strongly affected by the concentration of serum. Interestingly, single-walled carbon nanotube (SWNT) thin films were found to be the most effective substrate for the proliferation of Saos-2 cells in low concentrations of serum. Thus, thin SWNT films may be used as an effective biomaterial for the culture of Saos-2 cells in low serum concentrations.
Type: article (author version)
URI: http://hdl.handle.net/2115/48563
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 赤坂 司

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