| Title: | A fatal case of cytomegalovirus ventriculoencephalitis in a mycosis fungoides patient who received multiple umbilical cord blood cell transplantations |
| Authors: | Matsukawa, Toshihiro Browse this author |
| Goto, Hideki Browse this author |
| Takahashi, Kenta Browse this author |
| Asanuma, Shinsuke Browse this author |
| Yasumoto, Atsushi Browse this author |
| Takahata, Mutsumi Browse this author |
| Shigematsu, Akio Browse this author |
| Endo, Tomoyuki Browse this author |
| Tanaka, Junji Browse this author |
| Hashino, Satoshi Browse this author |
| Tanaka, Shinya Browse this author |
| Imamura, Masahiro Browse this author |
| Keywords: | Cytomegalovirus ventriculoencephalitis |
| Ganciclovir resistance |
| Umbilical cord blood transplantation |
| Mycosis fungoides |
| Inclusion-bearing cells |
| Issue Date: | Feb-2012 |
| Publisher: | Springer Japan |
| Journal Title: | International Journal of Hematology |
| Volume: | 95 |
| Issue: | 2 |
| Start Page: | 217 |
| End Page: | 222 |
| Publisher DOI: | 10.1007/s12185-012-1003-3 |
| PMID: | 22262140 |
| Abstract: | Cytomegalovirus (CMV) infection is latent in the majority of adult humans. The reactivation of CMV causes pneumonia and gastrointestinal disease in severely immunosuppressed patients, who consequently suffer very high mortality due to CMV central nervous system disease. We report here a case involving a 28-year-old female patient with mycosis fungoides who underwent umbilical cord blood transplantation three times and developed CMV ventriculoencephalitis. The patient's CMV viremia was successfully preempted with ganciclovir (GCV) as indicated by undetectable CMV antigenemia, but despite this successful treatment, the patient developed CMV ventriculoencephalitis. Foscarnet (FCV) therapy led to a temporary recovery, after which CMV ventriculoencephalitis recurred and the patient died after receiving combination GCV and FCV therapy. Autopsy samples revealed CMV ventriculoencephalitis, as indicated by numerous inclusion-bearing cells (Owl's eye). It is likely that this patient harbored a GCV-resistant CMV strain; however, it was not possible to obtain nucleic acids suitable for use in assessing this possibility. |
| Rights: | The final publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/48608 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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