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Validation Study on the Accuracy of Echocardiographic Measurements of Right Ventricular Systolic Function in Pulmonary Hypertension

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Title: Validation Study on the Accuracy of Echocardiographic Measurements of Right Ventricular Systolic Function in Pulmonary Hypertension
Authors: Sato, Takahiro Browse this author
Tsujino, Ichizo Browse this author →KAKEN DB
Ohira, Hiroshi Browse this author
Oyama-Manabe, Noriko Browse this author
Yamada, Asuka Browse this author
Ito, Yoichi M. Browse this author
Goto, Chisa Browse this author
Watanabe, Taku Browse this author
Sakaue, Shinji Browse this author
Nishimura, Masaharu Browse this author
Keywords: Pulmonary hypertension
Echocardiography
Right ventricular systolic function
Tricuspid annular plane systolic excursion
Issue Date: Mar-2012
Publisher: Mosby
Journal Title: Journal of the American Society of Echocardiography
Volume: 25
Issue: 3
Start Page: 280
End Page: 286
Publisher DOI: 10.1016/j.echo.2011.12.012
PMID: 22230250
Abstract: Background: Accuracy of echocardiographic parameters of right ventricular (RV) function has not been sufficiently validated in patients with pulmonary hypertension (PH). We attempted to evaluate whether echocardiographic measurements reliably reflect RV systolic function in PH using cardiac magnetic resonance imaging (CMRI)-derived RV ejection fraction (EF) as a gold standard. Materials and Methods: A total of thirty-seven consecutive patients with PH, 20 with pulmonary arterial hypertension, 12 with chronic thromboembolic pulmonary hypertension, and 5 others, were prospectively studied. All patients underwent echocardiography, CMRI and right heart catheterization within a 1-week interval. Associations between 5 echocardiography-derived parameters of RV systolic function and CMRI-derived RVEF were evaluated. Results: All 5 echocardiography-derived parameters were significantly correlated with CMRI-derived RVEF (%RV fractional shortening: r=0.48, p=0.0011; %RV area change: r=0.40, p=0.0083; tricuspid annular plane systolic excursion (TAPSE): r=0.86, p<0.0001, RV myocardial performance index: r=-0.59, p<0.0001; and systolic lateral tricuspid annular motion velocity (TVlat): r=0.63, p<0.0001). When compared with the other indices, TAPSE exhibited the highest correlation coefficient. Of the 5 echocardiographic measurements, only TAPSE significantly predicted CMRI-derived RVEF in multiple regression analysis (p<0.0001). Intra- and interobserver reproducibility was favorable for all 5 indices, and for TAPSE and TVlat was particularly high. Conclusion: Echocardiographic measurements are promising noninvasive indices of RV systolic function in patients with PH. In particular, TAPSE is superior to other indices in accuracy.
Type: article (author version)
URI: http://hdl.handle.net/2115/48647
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 辻野 一三

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