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Hokkaido University Collection of Scholarly and Academic Papers >
Societies >
北海道歯学雑誌 >
第32巻 第2号 >
Bone-Orchestrating Cells, Osteocytes
| Title: | Bone-Orchestrating Cells, Osteocytes |
| Authors: | Hongo, Hiromi Browse this author | | Hasegawa, Tomoka Browse this author | | Sasaki, Muneteru Browse this author | | Suzuki, Reiko Browse this author →KAKEN DB | | Masuki, Hideo Browse this author | | Yamada, Tamaki Browse this author | | Shimoji, Shinji Browse this author | | Kawanami, Masamitsu Browse this author →KAKEN DB | | Yamamoto, Tsuneyuki Browse this author | | Amizuka, Norio Browse this author →KAKEN DB |
| Keywords: | osteocyte | | OLCS | | sclerostin | | FGF23 | | bone remodeling |
| Issue Date: | Mar-2012 |
| Publisher: | 北海道歯学会 |
| Journal Title: | 北海道歯学雑誌 |
| Volume: | 32 |
| Issue: | 2 |
| Start Page: | 93 |
| End Page: | 103 |
| Abstract: | Osteocytes build up functional syncytia, i.e., the osteocytic lacunar-canalicular system（OLCS）. The osteocytes are interconnected through gap junctions between their cytoplasmic processes, which pass through narrow passageways referred to as osteocytic canaliculi. There are two possible ways, in which molecules can be transported throughout the OLCS: via the cytoplasmic processes and their gap junctions, and via the pericellular space in the osteocytic canaliculi. Transport of minerals and small molecules through a spatially well-organized OLCS appears to be pivotal for bone mineral homeostasis and bone remodeling control. Recently, osteocyte-derived molecules -- sclerostin, dentin matrix protein-1, fibroblast growth factor 23（FGF23）-- have been put in evidence as they may be related to osteocytic functions such as regulation of bone remodeling and so forth. Osteocytes were shown to regulate phosphorus serum levels and osteoblastic activity through the expression of FGF23 and sclerostin. In our observations, FGF23 and sclerostin synthesis seemed to be associated with the spatial regularity of the OLCS: both proteins were consistently expressed by osteocytes in epiphyses and cortical bones showing regularly arranged OLCS. In contrast, mice bearing high bone turnover, e.g., osteoprotegerin deficient mice, revealed markedly-diminished sclerostin. This review will introduce our recent studies on the regularity of OLCS and the osteocytic function. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/48704 |
| Appears in Collections: | 北海道歯学雑誌 > 第32巻 第2号
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Submitter: 網塚 憲生
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