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Bone-Orchestrating Cells, Osteocytes

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Title: Bone-Orchestrating Cells, Osteocytes
Authors: Hongo, Hiromi Browse this author
Hasegawa, Tomoka Browse this author
Sasaki, Muneteru Browse this author
Suzuki, Reiko Browse this author →KAKEN DB
Masuki, Hideo Browse this author
Yamada, Tamaki Browse this author
Shimoji, Shinji Browse this author
Kawanami, Masamitsu Browse this author →KAKEN DB
Yamamoto, Tsuneyuki Browse this author
Amizuka, Norio Browse this author →KAKEN DB
Keywords: osteocyte
bone remodeling
Issue Date: Mar-2012
Publisher: 北海道歯学会
Journal Title: 北海道歯学雑誌
Volume: 32
Issue: 2
Start Page: 93
End Page: 103
Abstract: Osteocytes build up functional syncytia, i.e., the osteocytic lacunar-canalicular system(OLCS). The osteocytes are interconnected through gap junctions between their cytoplasmic processes, which pass through narrow passageways referred to as osteocytic canaliculi. There are two possible ways, in which molecules can be transported throughout the OLCS: via the cytoplasmic processes and their gap junctions, and via the pericellular space in the osteocytic canaliculi. Transport of minerals and small molecules through a spatially well-organized OLCS appears to be pivotal for bone mineral homeostasis and bone remodeling control. Recently, osteocyte-derived molecules -- sclerostin, dentin matrix protein-1, fibroblast growth factor 23(FGF23)-- have been put in evidence as they may be related to osteocytic functions such as regulation of bone remodeling and so forth. Osteocytes were shown to regulate phosphorus serum levels and osteoblastic activity through the expression of FGF23 and sclerostin. In our observations, FGF23 and sclerostin synthesis seemed to be associated with the spatial regularity of the OLCS: both proteins were consistently expressed by osteocytes in epiphyses and cortical bones showing regularly arranged OLCS. In contrast, mice bearing high bone turnover, e.g., osteoprotegerin deficient mice, revealed markedly-diminished sclerostin. This review will introduce our recent studies on the regularity of OLCS and the osteocytic function.
Type: article
Appears in Collections:北海道歯学雑誌 = Hokkaido Journal of Dental Science > 第32巻 第2号

Submitter: 網塚 憲生


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