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Cancer early dissemination : cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor β signalling

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Title: Cancer early dissemination : cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor β signalling
Authors: Sabe, Hisataka Browse this author →KAKEN DB
Keywords: cancer stem cells
EMT
p53
TGFβ
tumor dissemination
Issue Date: Jun-2011
Publisher: Oxford University Press
Journal Title: Journal of Biochemistry
Volume: 149
Issue: 6
Start Page: 633
End Page: 639
Publisher DOI: 10.1093/jb/mvr044
PMID: 21478191
Abstract: Contrary to the long believed hypothesis, it is now evident that breast cancer cells can disseminate from the early phases of the oncogenesis; and that such early disseminated cells sometimes survive at the sites of dissemination and may outgrow after a long latency of years and decades. For cancer cells to leave their origin, they must at least transiently loosen their adhesion with adjacent epithelial cells and stroma, and become motile while avoiding anoikis. Such processes resemble epithelial-mesenchymal transdifferentiation (EMT), which normally takes place in situations such as embryogenesis and wound healing. Interestingly, the occurrence of an EMT-like process in breast cancer cells has been implicated in the generation of cancer stem-like cells, in which TGFβ1 signaling often plays core roles. Here, I discuss the current knowledge regarding cancerous EMT and its signaling pathways with the aim to consider the possible mechanisms of early dissemination, and also the generation of cancer stem-like cells in mammary tumor.
Rights: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in The Journal of Biochemistry following peer review. The definitive publisher-authenticated version J Biochem (2011) 149 (6): 633-639 is available online at: http://jb.oxfordjournals.org/content/149/6/633
Type: article (author version)
URI: http://hdl.handle.net/2115/48853
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐邊 壽孝

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