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Effects of Maternal 5,10-Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Tobacco Smoking on Infant Birth Weight in a Japanese Population

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Title: Effects of Maternal 5,10-Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Tobacco Smoking on Infant Birth Weight in a Japanese Population
Authors: Yila, Thamar Ayo Browse this author
Sasaki, Seiko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Braimoh, Titilola Serifat Browse this author
Kashino, Ikuko Browse this author
Kobayashi, Sumitaka Browse this author →KAKEN DB
Okada, Emiko Browse this author →KAKEN DB
Baba, Toshiaki Browse this author
Yoshioka, Eiji Browse this author →KAKEN DB
Minakami, Hisanori Browse this author →KAKEN DB
Endo, Toshiaki Browse this author →KAKEN DB
Sengoku, Kazuo Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: birth weight
tobacco smoking
Issue Date: 2012
Publisher: Japan Epidemiological Association
Journal Title: Journal of Epidemiology
Volume: 22
Issue: 2
Start Page: 91
End Page: 102
Publisher DOI: 10.2188/jea.JE20110039
Abstract: Background: Intracellular folate hemostasis depends on the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. Because 5,10-MTHFR 677TT homozygosity and tobacco smoking are associated with low folate status, we tested the hypothesis that smoking in mothers with 5,10-MTHFR C677T or A1298C polymorphisms would be independently associated with lower birth weight among their offspring. Methods: We assessed 1784 native Japanese mother-child pairs drawn from the ongoing birth cohort of The Hokkaido Study on Environment and Children's Health. Data (demographic information, hospital birth records, and biological specimens) were extracted from recruitments that took place during the period from February 2003 to March 2006. Maternal serum folate were assayed by chemiluminescent immunoassay, and genotyping of 5,10-MTHFR C677T/A1298C polymorphisms was done using a TaqMan allelic discrimination assay. Results: The prevalence of folate deficiency (< 6.8 nmol/L) was 0.3%. The 5,10-MTHFR 677CT genotype was independently associated with an increase of 36.40 g (95% CI: 2.60 to 70.30, P = 0.035) in mean infant birth weight and an increase of 90.70 g (95% CI: 6.00 to 175.50, P = 0.036) among male infants of nonsmokers. Female infants of 677TT homozygous passive smokers were 99.00 g (95% CI: -190.26 to -7.56, P = 0.034) lighter. The birth weight of the offspring of smokers with 5,10-MTHFR 1298AA homozygosity was lower by 107.00 g (95% CI: -180.00 to -33.90, P = 0.004). Conclusions: The results suggest that, in this population, maternal 5,10-MTHFR C677T polymorphism, but not the 5,10-MTHFR A1298C variant, is independently associated with improvement in infant birth weight, especially among nonsmokers. However, 5,10-MTHFR 1298AA might be associated with folate impairment and could interact with tobacco smoke to further decrease birth weight.
Rights: Copyright © 2012 by the Japan Epidemiological Association
Type: article
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: Thamar Yila Ayo

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