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Inhibitory Potencies of Bromophenols from Rhodomelaceae algae against α-Glucosidase Activity

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Title: Inhibitory Potencies of Bromophenols from Rhodomelaceae algae against α-Glucosidase Activity
Authors: Kurihara, Hideyuki Browse this author →KAKEN DB
Mitani, Takeshi Browse this author
Kawabata, Jun Browse this author →KAKEN DB
Takahashi, Koretaro Browse this author →KAKEN DB
Keywords: Symphyocladia latiuscula
Odonthalia corymbifera
Polysiphonia morrowii
Issue Date: 1999
Publisher: Japanese Society of Fisheries Science
Journal Title: Fisheries Science
Volume: 65
Issue: 2
Start Page: 300
End Page: 303
Publisher DOI: 10.2331/fishsci.65.300
Abstract: Inhibitory potencies against α-glucosidase activities were compared among bromophenols obtained from extracts of three Rhodomelaceae red algae, Symphyocladia latiuscula, Odonthalia corymbifera, and Polysiphonia morrowii. The bromophenols from these species are characterized by a number of Br atoms per benzene ring: S. latiuscula, three Br atoms (1 and 2); O. corymbifera, two Br atoms (3-7); and P. morrowii, one Br atom (8 and 9). The bromophenols exhibited mixed inhibition against yeast α-glucosidase reaction. In particular, symmetric dibenzyl ethers, bis(2,3,6-tribromo-4,5-dihydroxybenzyl) ether (2) and bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (5), exhibited about 10^3 fold smaller K_i values than the other bromophenols. Their inhibition modes are disclosed to be mixed inhibition closed to competitive inhibition. Inhibitory potencies of the bromophenols increased with the increasing degree of bromo-substitution per benzene ring and the decreasing degree of methyl-substitution. In contrast to the strong inhibitory activity against yeast α-glucosidase activity, the bromophenols moderately inhibited rat-intestinal sucrase and maltase activity. The inhibitory potencies were all comparative among the bromophenols examined.
Type: article
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高橋 是太郎

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