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Hokkaido University Collection of Scholarly and Academic Papers >
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Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus
| Title: | Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus |
| Authors: | Yabe, Ichiro Browse this author →KAKEN DB | | Tsuji-Akimoto, Sachiko Browse this author | | Shiga, Tohru Browse this author →KAKEN DB | | Hamada, Shinsuke Browse this author | | Hirata, Kenji Browse this author →KAKEN DB | | Otsuki, Mika Browse this author | | Kuge, Yuji Browse this author →KAKEN DB | | Tamaki, Nagara Browse this author →KAKEN DB | | Sasaki, Hidenao Browse this author →KAKEN DB |
| Keywords: | Amyotrophic lateral sclerosis | | Writing error | | Cognitive dysfunction | | PET | | Anterior cingulate gyrus |
| Issue Date: | 15-Apr-2012 |
| Publisher: | Elsevier |
| Journal Title: | Journal of the neurological sciences |
| Volume: | 315 |
| Issue: | 1-2 |
| Start Page: | 55 |
| End Page: | 59 |
| Publisher DOI: | 10.1016/j.jns.2011.11.039 |
| PMID: | 22226010 |
| Abstract: | Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by loss of motor neuron and various cognitive deficits including writing errors. (11)C-flumazenil (FMZ), the positron emission tomography (PET) GABA(A) receptor ligand, is a marker of cortical dysfunction. The objective of this study was to investigate the relationship between cognitive deficits and loss of neuronal integrity in ALS patients using (11)C-FMZ PET. Ten patients with ALS underwent both neuropsychological tests and (11)C-FMZ-PET. The binding potential (BP) of FMZ was calculated from (11)C-FMZ PET images. There were no significant correlations between the BP and most test scores except for the writing error index (WEI), which was measured by the modified Western Aphasia Battery - VB (WAB-IVB) test. The severity of writing error was associated with loss of neuronal integrity in the bilateral anterior cingulate gyrus with mild right predominance (n=9; x=4mm, y=36mm, z=4mm, Z=5.1). The results showed that writing errors in our patients with ALS were related to dysfunction in the anterior cingulate gyrus. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/49001 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 矢部 一郎
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