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Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus

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Title: Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus
Authors: Yabe, Ichiro Browse this author →KAKEN DB
Tsuji-Akimoto, Sachiko Browse this author
Shiga, Tohru Browse this author →KAKEN DB
Hamada, Shinsuke Browse this author
Hirata, Kenji Browse this author →KAKEN DB
Otsuki, Mika Browse this author
Kuge, Yuji Browse this author →KAKEN DB
Tamaki, Nagara Browse this author →KAKEN DB
Sasaki, Hidenao Browse this author →KAKEN DB
Keywords: Amyotrophic lateral sclerosis
Writing error
Cognitive dysfunction
PET
Anterior cingulate gyrus
Issue Date: 15-Apr-2012
Publisher: Elsevier
Journal Title: Journal of the neurological sciences
Volume: 315
Issue: 1-2
Start Page: 55
End Page: 59
Publisher DOI: 10.1016/j.jns.2011.11.039
PMID: 22226010
Abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by loss of motor neuron and various cognitive deficits including writing errors. (11)C-flumazenil (FMZ), the positron emission tomography (PET) GABA(A) receptor ligand, is a marker of cortical dysfunction. The objective of this study was to investigate the relationship between cognitive deficits and loss of neuronal integrity in ALS patients using (11)C-FMZ PET. Ten patients with ALS underwent both neuropsychological tests and (11)C-FMZ-PET. The binding potential (BP) of FMZ was calculated from (11)C-FMZ PET images. There were no significant correlations between the BP and most test scores except for the writing error index (WEI), which was measured by the modified Western Aphasia Battery - VB (WAB-IVB) test. The severity of writing error was associated with loss of neuronal integrity in the bilateral anterior cingulate gyrus with mild right predominance (n=9; x=4mm, y=36mm, z=4mm, Z=5.1). The results showed that writing errors in our patients with ALS were related to dysfunction in the anterior cingulate gyrus.
Type: article (author version)
URI: http://hdl.handle.net/2115/49001
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 矢部 一郎

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