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The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes.

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Title: The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes.
Authors: Araki, Atsuko Browse this author →KAKEN DB
Kanazawa, Ayako Browse this author →KAKEN DB
Kawai, Toshio Browse this author
Eitaki, Yoko Browse this author
Morimoto, Kanehisa Browse this author
Nakayama, Kunio Browse this author →KAKEN DB
Shibata, Eiji Browse this author →KAKEN DB
Tanaka, Masatoshi Browse this author
Takigawa, Tomoko Browse this author →KAKEN DB
Yoshimura, Takesumi Browse this author →KAKEN DB
Chikara, Hisao Browse this author
Saijo, Yasuaki Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Microbial volatile organic compounds (MVOCs)
Home environment
Issue Date: 15-Apr-2012
Publisher: Elsevier
Journal Title: The Science of the total environment
Volume: 423
Start Page: 18
End Page: 26
Publisher DOI: 10.1016/j.scitotenv.2012.02.026
PMID: 22405561
Abstract: Microbial volatile organic compounds (MVOCs) are a type of VOCs produced by microorganisms. Exposure to 1-octen-3-ol, one of the known MVOCs, has been reported to reduce nasal patency and increase nasal lavage myeloperoxidase, eosinophil cationic proteins, and lysozymes in both experimental and field studies. We reported in a previous paper that 1-octen-3-ol exposure at home is associated with mucosal symptoms. In this study, our aim was to investigate the relationship between asthma and allergies and MVOC exposure in single-family homes. The subjects were 624 inhabitants of 182 detached houses in six regions of Japan. Air samples were collected using diffusive samplers, and the concentrations of eight selected MVOCs were analyzed using gas chromatography/mass spectrometry in selected-ion-monitoring mode. Each inhabitant of each of the dwellings was given a self-administered questionnaire. Among the 609 subjects who answered all of the questions about allergies, history of the medical treatment for asthma, atopic dermatitis, allergic rhinitis, and allergic conjunctivitis within the preceding two years was 4.8%, 9.9%, 18.2%, and 7.1%, respectively. A significant association between 1-octen-3-ol (per log10 unit) and allergic rhinitis odds ratio (OR): 4.10, 95% confidence interval (CI): 1.71 to 9.80 and conjunctivitis (OR: 3.54, CI: 1.17 to 10.7) was found after adjusting for age, sex, tobacco, wall-to-wall carpeting, signs of dampness, history of treatment for hay fever, and other potentially relevant environmental factors. No relationships were found between any MVOCs and asthma or atopic dermatitis after the adjustment. The levels of MVOCs and airborne fungi were only weakly correlated. These results are consistent with previous studies that have associated higher levels of 1-octen-3-ol exposure with increased irritation of nasal and ocular mucosae. Although the indoor-air concentrations of 1-octen-3-ol found in this study were relatively low, we conclude that exposure to MVOC may be related to rhinitis and conjunctivitis.
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 荒木 敦子

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