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CD8+ tumor-infiltrating lymphocytes predict favorable prognosis in malignant pleural mesothelioma after resection

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Title: CD8+ tumor-infiltrating lymphocytes predict favorable prognosis in malignant pleural mesothelioma after resection
Authors: Yamada, Noriyuki Browse this author
Oizumi, Satoshi Browse this author →KAKEN DB
Kikuchi, Eiki Browse this author
Shinagawa, Naofumi Browse this author
Konishi-Sakakibara, Jun Browse this author
Ishimine, Atsushi Browse this author
Aoe, Keisuke Browse this author
Gemba, Kenichi Browse this author
Kishimoto, Takumi Browse this author
Torigoe, Toshihiko Browse this author
Nishimura, Masaharu Browse this author →KAKEN DB
Keywords: Malignant pleural mesothelioma
HLA class I
Tumor-infiltrating lymphocytes (TIL)
Issue Date: Oct-2010
Publisher: Springer Berlin / Heidelberg
Journal Title: Cancer Immunology, Immunotherapy
Volume: 59
Issue: 10
Start Page: 1543
End Page: 1549
Publisher DOI: 10.1007/s00262-010-0881-6
PMID: 20567822
Abstract: Defects in human leukocyte antigen (HLA) class I expression may allow tumor cells to escape immune recognition. T-cell infiltration is associated with a good prognosis in many cancers. However, the role of HLA class I expression and tumor-infiltrating lymphocytes (TILs) in malignant pleural mesothelioma (MPM) has not been fully analyzed. In the present study, we investigated the immune profiles and conducted outcome analyses of MPM patients. HLA class I expression and TILs (CD4+, CD8+, and NK cells) were detected by immunohistochemistry in a series of 44 MPM cases. To detect HLA class I expression, specimens were stained with the anti-pan HLA class I monoclonal antibody EMR8-5. The expression of HLA class I was positive in all patients. There was no case that showed negative HLA class I expression. The density of CD4+ and CD8+ TILs were strongly correlated (R = 0.76, p < 0.001). A high density of CD8+ TILs was a significantly better prognostic factor for the survival of patients with extrapleural pneumonectomy (p < 0.05). Multivariate analysis revealed that a high density of CD8+ TILs is an independent prognostic factor for patients who underwent extrapleural pneumonectomy. The presence of intratumoral CD8+ T cells was correlated with an improved clinical outcome, raising the possibility that CD8+ T cells might play a pivotal role in the anti-tumor immune response against MPMs. Thus, the stimulation of CD8+ lymphocytes might be an efficacious immunotherapy for MPM patients.
Rights: The final publication is available at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大泉 聡史

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