| Title: | CD8+ tumor-infiltrating lymphocytes predict favorable prognosis in malignant pleural mesothelioma after resection |
| Authors: | Yamada, Noriyuki Browse this author |
| Oizumi, Satoshi Browse this author →KAKEN DB |
| Kikuchi, Eiki Browse this author |
| Shinagawa, Naofumi Browse this author |
| Konishi-Sakakibara, Jun Browse this author |
| Ishimine, Atsushi Browse this author |
| Aoe, Keisuke Browse this author |
| Gemba, Kenichi Browse this author |
| Kishimoto, Takumi Browse this author |
| Torigoe, Toshihiko Browse this author |
| Nishimura, Masaharu Browse this author →KAKEN DB |
| Keywords: | Malignant pleural mesothelioma |
| HLA class I |
| Tumor-infiltrating lymphocytes (TIL) |
| Immunohistochemistry |
| Immunotherapy |
| Issue Date: | Oct-2010 |
| Publisher: | Springer Berlin / Heidelberg |
| Journal Title: | Cancer Immunology, Immunotherapy |
| Volume: | 59 |
| Issue: | 10 |
| Start Page: | 1543 |
| End Page: | 1549 |
| Publisher DOI: | 10.1007/s00262-010-0881-6 |
| PMID: | 20567822 |
| Abstract: | Defects in human leukocyte antigen (HLA) class I expression may allow tumor cells to escape immune recognition. T-cell infiltration is associated with a good prognosis in many cancers. However, the role of HLA class I expression and tumor-infiltrating lymphocytes (TILs) in malignant pleural mesothelioma (MPM) has not been fully analyzed. In the present study, we investigated the immune profiles and conducted outcome analyses of MPM patients. HLA class I expression and TILs (CD4+, CD8+, and NK cells) were detected by immunohistochemistry in a series of 44 MPM cases. To detect HLA class I expression, specimens were stained with the anti-pan HLA class I monoclonal antibody EMR8-5. The expression of HLA class I was positive in all patients. There was no case that showed negative HLA class I expression. The density of CD4+ and CD8+ TILs were strongly correlated (R = 0.76, p < 0.001). A high density of CD8+ TILs was a significantly better prognostic factor for the survival of patients with extrapleural pneumonectomy (p < 0.05). Multivariate analysis revealed that a high density of CD8+ TILs is an independent prognostic factor for patients who underwent extrapleural pneumonectomy. The presence of intratumoral CD8+ T cells was correlated with an improved clinical outcome, raising the possibility that CD8+ T cells might play a pivotal role in the anti-tumor immune response against MPMs. Thus, the stimulation of CD8+ lymphocytes might be an efficacious immunotherapy for MPM patients. |
| Rights: | The final publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/49187 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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