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Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes

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Title: Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes
Authors: Shimada, Kohei Browse this author
Ohno, Yuta Browse this author
Okamatsu-Ogura, Yuko Browse this author →KAKEN DB
Suzuki, Masahiro Browse this author
Kamikawa, Akihiro Browse this author
Terao, Akira Browse this author →KAKEN DB
Kimura, Kazuhiro Browse this author →KAKEN DB
Keywords: BAT
Norepinephrine
p44/p42 MAPK
NPY
STAT
Thermogenesis
Issue Date: Apr-2012
Publisher: Elsevier
Journal Title: Peptides
Volume: 34
Issue: 2
Start Page: 336
End Page: 342
Publisher DOI: 10.1016/j.peptides.2012.02.012
PMID: 22374387
Abstract: The thermogenic function of brown adipose tissue (BAT) is increased by norepinephrine (NE) released from sympathetic nerve endings, but the roles of NPY released along with NE are poorly elucidated. Here, we examined effect of NPY on basal and NE-enhanced thermogenesis in isolated brown adipocytes that express Y1 and Y5 receptor mRNA. Treatment of cells with NPY did not influence the basal and NE-enhanced rates of oxygen consumption and cAMP accumulation. Treatment with NPY also failed to induce ERK (Thr202/Tyr204) phosphorylation in the brown adipocytes. In contrast, treatment with NPY increased ERK phosphorylation in cultured stromal vascular cells from the BAT that express Y1 receptor mRNA. In the latter treatment with NPY also increased STAT3 (Ser727) phosphorylation. These results suggest that NPY mainly acts on stromal vascular cells in BAT and plays roles in the regulation of their gene transcription through ERK and STAT3 pathways, while NPY does not affect the thermogenic function of brown adipocytes.
Type: article (author version)
URI: http://hdl.handle.net/2115/49225
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 木村 和弘

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