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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Successful Kidney Transplantation Ameliorates Arterial Stiffness in End-Stage Renal Disease Patients
| Title: | Successful Kidney Transplantation Ameliorates Arterial Stiffness in End-Stage Renal Disease Patients |
| Authors: | Hotta, Kiyohiko Browse this author | | Harada, Hiroshi Browse this author | | Sasaki, Hajime Browse this author | | Iwami, Daiki Browse this author →KAKEN DB | | Fukuzawa, Nobuyuki Browse this author | | Morita, Ken Browse this author | | Seki, Toshimori Browse this author | | Togashi, Masaki Browse this author | | Nonomura, Katsuya Browse this author →KAKEN DB |
| Issue Date: | Apr-2012 |
| Publisher: | Elsevier |
| Journal Title: | Transplantation Proceedings |
| Volume: | 44 |
| Issue: | 3 |
| Start Page: | 684 |
| End Page: | 686 |
| Publisher DOI: | 10.1016/j.transproceed.2011.11.016 |
| PMID: | 22483468 |
| Abstract: | Purpose: Successful kidney transplantation (KTx) can ameliorate bodily damage caused by end-stage renal disease (ESRD). Arterial stiffness (AS) is one of the critical factors, that shorten the survival of patients due to cardiovascular events. KTx may reduce AS as well; however, this has not been investigated well. We therefore conducted a retrospective study using non-invasive pulse wave velocity (PWV), which is a useful index of aortic damage. Patients and methods: Fifty-eight consecutive kidney recipients (34 men, 24 women) were enrolled in this study. Mean age at transplantation was 40.5±12.3 years and the dialysis period was 73.1±95.8 months. The brachial-ankle PWV was measured preoperatively and six months postoperatively. First, we investigated the relationship between the PWV and the other parameters related to AS. Second, we studied the pre- to post-transplant change in PWV to evaluate the amelioration of AS after successful kidney transplantation. Results: PWV showed significant positive correlations with age, systolic blood pressure (BP), diastolic BP and abdominal aortic calcification index. After successful KTx, PWV significantly decreased. (P < 0.01) In addition, systolic and diastolic BP significantly decreased. (P < 0.01 and P < 0.05, respectively) Conclusion: Successful KTx ameliorates AS in ESRD patients. This might explain the improved cardiovascular prognosis of ESRD patients who undergo kidney transplantation. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/49270 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 野々村 克也
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