| Title: | Screening for diabetes using Japanese monitoring guidance in schizophrenia patients treated with second-generation antipsychotics : A cross-sectional study using baseline data |
| Authors: | Kusumi, Ichiro Browse this author →KAKEN DB |
| Ito, Koki Browse this author |
| Honda, Minoru Browse this author |
| Hayashishita, Tadayuki Browse this author |
| Uemura, Keiichi Browse this author |
| Hashimoto, Naoki Browse this author |
| Murasaki, Mitsukuni Browse this author |
| Atsumi, Yoshihito Browse this author |
| Kadowaki, Takashi Browse this author |
| Koyama, Tsukasa Browse this author →KAKEN DB |
| Keywords: | diabetes mellitus |
| glucose monitoring guidance |
| metabolic abnormality |
| schizophrenia |
| second-generation antipsychotic |
| Issue Date: | Jun-2011 |
| Publisher: | Blackwell Publishing |
| Journal Title: | Psychiatry and Clinical Neurosciences |
| Volume: | 65 |
| Issue: | 4 |
| Start Page: | 349 |
| End Page: | 355 |
| Publisher DOI: | 10.1111/j.1440-1819.2011.02218.x |
| PMID: | 21545674 |
| Abstract: | Aim: The Japanese blood glucose monitoring guidance for patients receiving second-generation antipsychotics has been newly developed. We aimed to report a cross-sectional study using a baseline data of the Japanese monitoring guidance to find undiagnosed hyperglycemia systematically as a routine clinical practice and to quantify the frequency of glucose abnormalities in schizophrenia patients treated with second-generation antipsychotics. Methods: Data for 537 patients with schizophrenia who had not been diagnosed as diabetes prior to baseline screening and started the monitoring between June 2008 and January 2009, were collected from medical records in 25 hospitals. Blood glucose (fasting or casual), hemoglobin_[A1c], serum lipids, height/weight, clinical diabetic symptoms, and family history of diabetes were assessed. Patients were classified into normal, pre-diabetic or probable diabetic type based on their values of blood glucose or hemoglobin_[A1c], and various background characteristics and serum lipid values were compared among the three types. Results: Out of 537 patients, 13 (2.4%) met criteria for probable diabetic type, 51 (9.5%) for pre-diabetic type, and 473 (88.1%) for normal type. Individuals categorized as probable diabetic type had a higher body mass index and higher frequency of family history of diabetes mellitus than those within normal type. Conclusion: Glucose abnormalities were newly detected in 11.9% of schizophrenia patients treated with second-generation antipsychotics by the baseline monitoring. To assess the detective power and usefulness of the guidance, longitudinal investigations are necessary. |
| Rights: | The definitive version is available at www.wileyonlinelibrary.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/49341 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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