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Screening for diabetes using Japanese monitoring guidance in schizophrenia patients treated with second-generation antipsychotics : A cross-sectional study using baseline data

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/49341

Title: Screening for diabetes using Japanese monitoring guidance in schizophrenia patients treated with second-generation antipsychotics : A cross-sectional study using baseline data
Authors: Kusumi, Ichiro Browse this author →KAKEN DB
Ito, Koki Browse this author
Honda, Minoru Browse this author
Hayashishita, Tadayuki Browse this author
Uemura, Keiichi Browse this author
Hashimoto, Naoki Browse this author
Murasaki, Mitsukuni Browse this author
Atsumi, Yoshihito Browse this author
Kadowaki, Takashi Browse this author
Koyama, Tsukasa Browse this author →KAKEN DB
Keywords: diabetes mellitus
glucose monitoring guidance
metabolic abnormality
schizophrenia
second-generation antipsychotic
Issue Date: Jun-2011
Publisher: Blackwell Publishing
Journal Title: Psychiatry and Clinical Neurosciences
Volume: 65
Issue: 4
Start Page: 349
End Page: 355
Publisher DOI: 10.1111/j.1440-1819.2011.02218.x
PMID: 21545674
Abstract: Aim: The Japanese blood glucose monitoring guidance for patients receiving second-generation antipsychotics has been newly developed. We aimed to report a cross-sectional study using a baseline data of the Japanese monitoring guidance to find undiagnosed hyperglycemia systematically as a routine clinical practice and to quantify the frequency of glucose abnormalities in schizophrenia patients treated with second-generation antipsychotics. Methods: Data for 537 patients with schizophrenia who had not been diagnosed as diabetes prior to baseline screening and started the monitoring between June 2008 and January 2009, were collected from medical records in 25 hospitals. Blood glucose (fasting or casual), hemoglobin_[A1c], serum lipids, height/weight, clinical diabetic symptoms, and family history of diabetes were assessed. Patients were classified into normal, pre-diabetic or probable diabetic type based on their values of blood glucose or hemoglobin_[A1c], and various background characteristics and serum lipid values were compared among the three types. Results: Out of 537 patients, 13 (2.4%) met criteria for probable diabetic type, 51 (9.5%) for pre-diabetic type, and 473 (88.1%) for normal type. Individuals categorized as probable diabetic type had a higher body mass index and higher frequency of family history of diabetes mellitus than those within normal type. Conclusion: Glucose abnormalities were newly detected in 11.9% of schizophrenia patients treated with second-generation antipsychotics by the baseline monitoring. To assess the detective power and usefulness of the guidance, longitudinal investigations are necessary.
Rights: The definitive version is available at www.wileyonlinelibrary.com
Type: article (author version)
URI: http://hdl.handle.net/2115/49341
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 久住 一郎

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