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Monitoring anti-interleukin 6 receptor antibody treatment for rheumatoid arthritis by quantitative magnetic resonance imaging of the hand and power Doppler ultrasonography of the finger

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Title: Monitoring anti-interleukin 6 receptor antibody treatment for rheumatoid arthritis by quantitative magnetic resonance imaging of the hand and power Doppler ultrasonography of the finger
Authors: Kamishima, Tamotsu Browse this author →KAKEN DB
Tanimura, Kazuhide Browse this author
Shimizu, Masato Browse this author
Matsuhashi, Megumi Browse this author
Fukae, Jun Browse this author
Kon, Yujiro Browse this author
Hagiwara, Hiromi Browse this author
Narita, Akihiro Browse this author
Aoki, Yuko Browse this author
Kosaka, Naoki Browse this author
Atsumi, Tatsuya Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Terae, Satoshi Browse this author →KAKEN DB
Keywords: Anti-interleukin 6 receptor antibody
Rheumatoid arthritis
Quantitative analysis
Magnetic resonance imaging
Power Doppler ultrasonography
Issue Date: Jun-2011
Publisher: Springer Berlin / Heidelberg
Journal Title: Skeletal Radiology
Volume: 40
Issue: 6
Start Page: 745
End Page: 755
Publisher DOI: 10.1007/s00256-010-1064-4
PMID: 21076827
Abstract: Objectives: To compare quantitative magnetic resonance imaging (MRI) and power Doppler ultrasonography (PDUS) with conventional measures of disease activity in rheumatoid arthritis (RA) patients with the anti-interleukin 6 (anti-IL 6) receptor tocilizumab in terms of responsiveness at a few months to disease activity and ability to predict structural damage at 1 year. Methods: A cohort of patients with RA (n = 29) was evaluated clinically including disease activity score 28 (DAS28) and by semiquantitative (SQ-) and quantitative (Q-) PDUS (bilateral metacarpophalangeal joints) and MRI (one hand and wrist) at initiation of treatment with anti-IL 6 receptor antibody agents and after 2 and 5 months. Conventional radiography for both hands and wrists was performed at baseline and at 12 months. Responsiveness was assessed by standardized response means (SRM). Areas under the curve (AUC) for measures at baseline, 2 and 5 months were correlated with structural damage at one year. Results: Among the laboratory and clinical parameters, DAS28-ESR was the most responsive with a large effect size of SRM. Structural damage progressions for radiography and MR erosion were correlated with AUC of MR bone erosion and Q-PDUS, respectively. Conclusions: In the evaluation of disease activity in RA patients in the first few months after starting anti-IL 6 receptor antibody tocilizumab treatment, the semi-quantitative MR bone erosion score of the hand and quantitative value for power Doppler signal in the finger joint were both responsive and predictive of structural damage progression at 1 year.
Rights: The final publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/49371
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 神島 保

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