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Tannin-fluoride preparation attenuates prostaglandin E2 production by dental pulp cells

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Title: Tannin-fluoride preparation attenuates prostaglandin E2 production by dental pulp cells
Authors: Nakamura, Koichi Browse this author
Deyama, Yoshiaki Browse this author →KAKEN DB
Yoshimura, Yoshitaka Browse this author →KAKEN DB
Hashimoto, Masanori Browse this author
Kaga, Masayuki Browse this author →KAKEN DB
Suzuki, Kuniaki Browse this author →KAKEN DB
Yawaka, Yasutaka Browse this author →KAKEN DB
Keywords: tannin-fluoride preparation
prostaglandin E2
dental pulp cells
Issue Date: Jul-2011
Publisher: Spandidos Publications
Journal Title: Molecular Medicine Reports
Volume: 4
Issue: 4
Start Page: 641
End Page: 644
Publisher DOI: 10.3892/mmr.2011.476
PMID: 21503579
Abstract: Glass ionomer cements (GICs) are widely used for the operative restoration of dental caries. However, it has been reported that the components of GICs cause pulpal inflammatory responses. Recently, GICs containing tannin-fluoride preparation (HY agent) were developed. In this study, we investigated the effect of HY agent on prostaglandin E2, (PGE2) release from GIC-stimulated rat dental pulp cells (RPC-C2A). Extracts derived from GIC disks were used with HY(+) and without HY(-) agent. After treatment with GIC extracts, ATP contents, COX-2 mRNA and protein expression in RPC-C2A cells, and PGE2 production in culture media were analyzed. HY agent suppressed HY(-)-stimulated PGE2 release from RPC-C2A cells, as well as COX-2 mRNA and protein expression. Moreover, tannic acid attenuated COX-2 mRNA induced by HY(-) extract in a dose-dependent manner. Taken together, these results suggest that tannic acid in HY agent may suppress GIC-induced production of PGE2 by inhibition of COX-2 expression in dental pulp cells.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 出山 義昭

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