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Signaling from Fibroblast Growth Factor Receptor 2 in Immature Hematopoietic Cells Facilitates Donor Hematopoiesis After Intra-Bone Marrow–Bone Marrow Transplantation

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Title: Signaling from Fibroblast Growth Factor Receptor 2 in Immature Hematopoietic Cells Facilitates Donor Hematopoiesis After Intra-Bone Marrow–Bone Marrow Transplantation
Authors: Shigematsu, Akio Browse this author
Shi, Ming Browse this author
Okigaki, Mitsuhiko Browse this author
Adachi, Yasushi Browse this author
Koike, Naoko Browse this author
Che, Jishan Browse this author
Iwasaki, Masayoshi Browse this author
Matsubara, Hiroaki Browse this author
Imamura, Masahiro Browse this author →KAKEN DB
Ikehara, Susumu Browse this author
Issue Date: 27-Oct-2010
Publisher: Mary Ann Liebert
Journal Title: Stem Cells and Development
Volume: 19
Issue: 11
Start Page: 1679
End Page: 1686
Publisher DOI: 10.1089/scd.2009.0370
Abstract: Fibroblast growth factor (FGF) and FGF receptor (FGFR) are expressed in various cells including endothelial progenitor cells and hematopoietic cells. The interaction between FGF and FGFR is associated with the proliferation, migration, and survival of these cells. In this report, we examined the effects of FGFR2 signaling on hematopoiesis in immature hematopoietic cells, using mutant mice in which a constitutively active form of FGFR2 mutant was caused to be overexpressed by the Tie2 promoter (FGFR2 Tg mice). Under normal conditions, hematopoiesis of FGFR2 Tg mice and wild type (Wt) mice do not differ significantly, except for the weight and cell numbers of the thymus. However, the c-kit+Sca-1+lineage- bone marrow cells (BMCs) of FGFR2 Tg mice facilitate the formation of colony-forming units of culture. When these BMCs were transplanted into the recipient bone marrow (intra-bone marrow-bone marrow transplantation), there was better reconstitution of donor hematopoietic cells. In the in vitro experiment, the c-kit+Sca-1+lineage- BMCs from FGFR2 Tg mice showed fewer apoptotic cells than those from Wt mice. These results suggest that the antiapoptotic effect of FGFR2 signaling facilitates the hematopoiesis of FGFR2 Tg mice.
Rights: This is a copy of an article published in the Stem Cells and Development © 2010 copyright Mary Ann Liebert, Inc.; Stem Cells and Development is available online at: http://www.liebertonline.com.
Type: article
URI: http://hdl.handle.net/2115/49550
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 今村 雅寛

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