| Title: | Successful treatment of acute myelogenous leukemia with favorable cytogenetics by reduced-intensity stem cell transplantation |
| Authors: | Kondo, Takeshi Browse this author →KAKEN DB |
| Yasumoto, Atsushi Browse this author |
| Arita, Kotaro Browse this author |
| Sugita, Jun-ichi Browse this author |
| Shigematsu, Akio Browse this author |
| Okada, Kohei Browse this author |
| Takahata, Mutsumi Browse this author |
| Onozawa, Masahiro Browse this author →KAKEN DB |
| Kahata, Kaoru Browse this author |
| Takeda, Yukari Browse this author |
| Obara, Masato Browse this author |
| Yamamoto, Satoshi Browse this author |
| Endo, Tomoyuki Browse this author |
| Nishio, Mitsufumi Browse this author →KAKEN DB |
| Sato, Norihiro Browse this author |
| Tanaka, Junji Browse this author →KAKEN DB |
| Hashino, Satoshi Browse this author →KAKEN DB |
| Koike, Takao Browse this author →KAKEN DB |
| Asaka, Masahiro Browse this author →KAKEN DB |
| Imamura, Masahiro Browse this author →KAKEN DB |
| Keywords: | AML |
| Favorable karyotype |
| RIST |
| Issue Date: | Mar-2010 |
| Publisher: | Springer Japan |
| Journal Title: | International Journal of Hematology |
| Volume: | 91 |
| Issue: | 2 |
| Start Page: | 310 |
| End Page: | 321 |
| Publisher DOI: | 10.1007/s12185-009-0487-y |
| PMID: | 20087795 |
| Abstract: | Acute myelogenous leukemia (AML) with favorable cytogenetics responds well to chemotherapy. If the leukemia relapses, allogenic hematopoietic stem transplantation (allo-HSCT) is considered as a treatment option. Since the efficacy of reduced-intensity stem cell transplantation (RIST) for AML with favorable cytogenetics has not been established, we retrospectively analyzed the outcomes of allo-HSCT in AML patients according to cytogenetic risks. The outcome of allo-HSCT for AML patients with favorable cytogenetics seemed to be superior to that for AML patients with intermediate cytogenetics. In AML patients with favorable cytogenetics, the 3-year overall survival (OS) and relapse-free survival (RFS) rates were 88% and 76%, respectively, in the RIST group. Both the 3-year OS and RFS rates were 81% in the conventional stem cell transplantation (CST) group. The outcome of RIST for AML patients with favorable cytogenetics was comparable to that for patients who received CST despite the more advanced age and greater organ dysfunction in RIST group than in CST group. None of the patients died within 90 days after RIST. Moreover, there was no relapse in patients with favorable cytogenetics who were in hematological remission prior to RIST. Thus, RIST for AML patients with favorable cytogenetics in remission is safe and effective. |
| Rights: | The final publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/49669 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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