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Efficacy of folinic acid in preventing oral mucositis in allogeneic hematopoietic stem cell transplant patients receiving MTX as prophylaxis for GVHD

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Title: Efficacy of folinic acid in preventing oral mucositis in allogeneic hematopoietic stem cell transplant patients receiving MTX as prophylaxis for GVHD
Authors: Sugita, Junichi Browse this author
Matsushita, Takae Browse this author
Kashiwazaki, Haruhiko Browse this author →KAKEN DB
Kosugi, Mizuha Browse this author
Takahashi, Shojiro Browse this author
Wakasa, Kentaro Browse this author
Shiratori, Souichi Browse this author
Ibata, Makoto Browse this author
Shono, Yusuke Browse this author
Shigematsu, Akio Browse this author
Obara, Masato Browse this author
Fujimoto, Katsuya Browse this author
Endo, Tomoyuki Browse this author
Nishio, Mitsufumi Browse this author →KAKEN DB
Kondo, Takeshi Browse this author →KAKEN DB
Hashino, Satoshi Browse this author →KAKEN DB
Tanaka, Junji Browse this author →KAKEN DB
Asaka, Masahiro Browse this author →KAKEN DB
Imamura, Masahiro Browse this author →KAKEN DB
Keywords: oral mucositis
folinic acid
stem cell transplantation
SCT
Issue Date: Feb-2012
Publisher: Nature Publishing Group
Journal Title: Bone Marrow Transplantation
Volume: 47
Issue: 2
Start Page: 258
End Page: 264
Publisher DOI: 10.1038/bmt.2011.53
PMID: 21423118
Abstract: Since the safety of folinic acid administration and its efficacy for reducing the toxicity of methotrexate (MTX) remain controversial, we assessed the effect of folinic acid administration after MTX treatment for GVHD prophylaxis on the incidence of oral mucositis and acute GVHD. We retrospectively analyzed data for 118 patients who had undergone allogeneic hematopoietic stem cell transplantation and had received MTX for GVHD prophylaxis. Multivariate analysis showed that systemic folinic acid administration significantly reduced the incidence of severe oral mucositis (OR = 0.13, 95%CI 0.04-0.73, P = 0.014). There was also a tendency for lower incidence of severe oral mucositis in patients who received folinic acid mouthwash (OR = 0.39, 95%CI 0.15-1.00, P = 0.051). No significant difference was observed in the incidence of acute GVHD between patients who received systemic folinic acid administration and those who did not (P = 0.88). Systemic folinic acid administration and mouthwash appear to be useful for reducing the incidence of severe oral mucositis in patients who have received allogeneic hematopoietic mucositis in patients who have received allogeneic hematopoietic stem cell transplantation using MTX as GVHD prophylaxis.
Type: article (author version)
URI: http://hdl.handle.net/2115/49685
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 杉田 純一

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