Title: | Efficacy of folinic acid in preventing oral mucositis in allogeneic hematopoietic stem cell transplant patients receiving MTX as prophylaxis for GVHD |
Authors: | Sugita, Junichi Browse this author |
Matsushita, Takae Browse this author |
Kashiwazaki, Haruhiko Browse this author →KAKEN DB |
Kosugi, Mizuha Browse this author |
Takahashi, Shojiro Browse this author |
Wakasa, Kentaro Browse this author |
Shiratori, Souichi Browse this author |
Ibata, Makoto Browse this author |
Shono, Yusuke Browse this author |
Shigematsu, Akio Browse this author |
Obara, Masato Browse this author |
Fujimoto, Katsuya Browse this author |
Endo, Tomoyuki Browse this author |
Nishio, Mitsufumi Browse this author →KAKEN DB |
Kondo, Takeshi Browse this author →KAKEN DB |
Hashino, Satoshi Browse this author →KAKEN DB |
Tanaka, Junji Browse this author →KAKEN DB |
Asaka, Masahiro Browse this author →KAKEN DB |
Imamura, Masahiro Browse this author →KAKEN DB |
Keywords: | oral mucositis |
folinic acid |
stem cell transplantation |
SCT |
Issue Date: | Feb-2012 |
Publisher: | Nature Publishing Group |
Journal Title: | Bone Marrow Transplantation |
Volume: | 47 |
Issue: | 2 |
Start Page: | 258 |
End Page: | 264 |
Publisher DOI: | 10.1038/bmt.2011.53 |
PMID: | 21423118 |
Abstract: | Since the safety of folinic acid administration and its efficacy for reducing the toxicity of methotrexate (MTX) remain controversial, we assessed the effect of folinic acid administration after MTX treatment for GVHD prophylaxis on the incidence of oral mucositis and acute GVHD. We retrospectively analyzed data for 118 patients who had undergone allogeneic hematopoietic stem cell transplantation and had received MTX for GVHD prophylaxis. Multivariate analysis showed that systemic folinic acid administration significantly reduced the incidence of severe oral mucositis (OR = 0.13, 95%CI 0.04-0.73, P = 0.014). There was also a tendency for lower incidence of severe oral mucositis in patients who received folinic acid mouthwash (OR = 0.39, 95%CI 0.15-1.00, P = 0.051). No significant difference was observed in the incidence of acute GVHD between patients who received systemic folinic acid administration and those who did not (P = 0.88). Systemic folinic acid administration and mouthwash appear to be useful for reducing the incidence of severe oral mucositis in patients who have received allogeneic hematopoietic mucositis in patients who have received allogeneic hematopoietic stem cell transplantation using MTX as GVHD prophylaxis. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/49685 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|