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Cytosine-phosphodiester-guanine oligodeoxynucleotide (CpG ODN)-capped hollow mesoporous silica particles for enzyme-triggered drug delivery
| Title: | Cytosine-phosphodiester-guanine oligodeoxynucleotide (CpG ODN)-capped hollow mesoporous silica particles for enzyme-triggered drug delivery |
| Authors: | Zhu, Yufang Browse this author | | Meng, Wenjun Browse this author | | Hanagata, Nobutaka Browse this author →KAKEN DB |
| Keywords: | Hollow mesoporous silica | | Controlled release | | CpG ODN | | Drug delivery |
| Issue Date: | 21-Oct-2011 |
| Publisher: | Royal Society of Chemistry |
| Journal Title: | Dalton Transactions |
| Volume: | 40 |
| Issue: | 39 |
| Start Page: | 10203 |
| End Page: | 10208 |
| Publisher DOI: | 10.1039/c1dt11114k |
| Abstract: | We designed, for the first time, an enzyme-triggered drug delivery system that is based on cytosine-phosphodiester-guanine oligodeoxynucleotide (CpG ODN)-capped hollow mesoporous silica (HMS) particles as carriers. Fluorescein dye was used as a model drug, and the fluorescein loading, amino-grafting and CpG ODN capping were evaluated by UV/Vis analysis, zeta potential and N2 adsorption-desorption measurements and gel electrophoresis. The fluorescein loading capacity and CpG ODN capping amount were 37.7 and 39.6 μg mg, respectively at the weight ratio of 10 Dye/HMS-NH2/CpG ODN. Importantly, fluorescein release can be triggered by the addition of deoxyribonuclease I (DNase I) for CpG ODN degradation, and the release rate can also be controlled by changing the DNase I concentration. Therefore, it might be a promising controlled drug delivery system for application in the field of biomedicine and cancer therapy. |
| Rights: | Dalton Trans., 2011, 40, 10203-10208 - Reproduced by permission of The Royal Society of Chemistry (RSC) |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/49727 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 花方 信孝
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