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Chiral separation of glycerolipids by high-performance liquid chromatography

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Title: Chiral separation of glycerolipids by high-performance liquid chromatography
Authors: Itabashi, Yutaka Browse this author →KAKEN DB
Keywords: Chiral separation
Diastereomers
Enantiomers
Glycerolipids
High-performance liquid chromatography
Mass spectrometry
Issue Date: 2012
Publisher: 日本脂質栄養学会
Journal Title: 脂質栄養学
Journal Title(alt): Journal of Lipid Nutrition
Volume: 21
Issue: 1
Start Page: 27
End Page: 34
Publisher DOI: 10.4010/jln.21.27
Abstract: Since the enantiomer resolution of synthetic mono- and diacylglycerols as 3,5-dinitrophenylurethanes was achieved by chiral-phase high-performance liquid chromatography (HPLC) in the 1980s, the methodology has been extended to the resolution of various synthetic and naturally occurring chiral glycerolipids. The recent development of polysaccharide-based chiral stationary phases along with optimized chromatographic elution conditions has permitted direct enantiomer resolution of mono-, di-, and triacylglycerols without previous derivatization. However, there are still some compounds for which enantiomer resolution is difficult to achieve, such as phosphatidylcholine and phosphatidylethanolamine. With the development of new derivatization reagents and chromatographic techniques, resolution of these difficult compounds may be possible in the near future. Chiral-phase HPLC will become considerably important in the future as a valuable tool for further expansion of the field of lipidomics and a better understanding of lipid metabolism.
Type: article
URI: http://hdl.handle.net/2115/49883
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 板橋 豊

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