Binding Mode of CpG Oligodeoxynucleotides to Nanoparticles Regulates Bifurcated Cytokine induction via Toll-like Receptor 9

Chinnathambi, Shanmugavel; Chen, Song; Ganesan, Singaravelu; Hanagata, Nobutaka

doi:10.1038/srep00534


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Binding Mode of CpG Oligodeoxynucleotides to Nanoparticles Regulates Bifurcated Cytokine induction via Toll-like Receptor 9

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Title:	Binding Mode of CpG Oligodeoxynucleotides to Nanoparticles Regulates Bifurcated Cytokine induction via Toll-like Receptor 9
Authors:	Chinnathambi, Shanmugavel Browse this author
	Chen, Song Browse this author
	Ganesan, Singaravelu Browse this author
	Hanagata, Nobutaka Browse this author →KAKEN DB
Keywords:	Immunology
	Nanobiotechnology
	Cell signalling
	Nanoparticles
Issue Date:	26-Jul-2012
Publisher:	Nature Publishing Group
Journal Title:	Scientific Reports
Volume:	2
Start Page:	534
Publisher DOI:	10.1038/srep00534
Abstract:	The interaction of cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODNs) with Toll-like receptor 9 (TLR9) activates the immune system. Multimeric class A CpG ODNs induce interferon-α (IFN-α) and, to a lesser extent, interleukin-6. By contrast, monomeric class B CpG ODNs induce interleukin-6 but not IFN-α. This difference suggests that the multimerization of CpG ODN molecules is a key factor in IFN-α induction. We multimerized class B CpG ODN2006x3-PD molecules that consist entirely of a phosphodiester backbone onto quantum dot silicon nanoparticles with various binding modes. Herein, we present the binding mode-dependent bifurcation of cytokine induction and discuss its possible mechanism of CpG ODN and TLR9 interaction. Our discoveries also suggest that nanoparticles play roles in not only delivery of CpG ODNs but also control of CpG ODN activity.
Rights:	http://creativecommons.org/licenses/by-nc-nd/3.0/
Type:	article
URI:	http://hdl.handle.net/2115/49944
Appears in Collections:	生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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