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Early diastolic mitral annular velocity at the interventricular septal annulus correctly reflects left ventricular longitudinal myocardial relaxation

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Title: Early diastolic mitral annular velocity at the interventricular septal annulus correctly reflects left ventricular longitudinal myocardial relaxation
Authors: Okada, Kazunori Browse this author
Mikami, Taisei Browse this author →KAKEN DB
Kaga, Sanae Browse this author
Onozuka, Hisao Browse this author
Inoue, Mamiko Browse this author
Yokoyama, Shinobu Browse this author
Nishino, Hisao Browse this author
Nishida, Mutsumi Browse this author →KAKEN DB
Matsuno, Kazuhiko Browse this author →KAKEN DB
Iwano, Hiroyuki Browse this author
Yamada, Satoshi Browse this author →KAKEN DB
Tsutsui, Hiroyuki Browse this author →KAKEN DB
Keywords: Tissue Doppler imaging
Early diastolic mitral annular velocity
Two-dimensional speckle tracking imaging
Left ventricular longitudinal myocardial relaxation
Issue Date: Dec-2011
Publisher: Oxford University Press
Journal Title: European Heart Journal, Cardiovascular Imaging
Volume: 12
Issue: 12
Start Page: 917
End Page: 923
Publisher DOI: 10.1093/ejechocard/jer154
PMID: 21908514
Abstract: Aims: Early diastolic mitral annular velocity (e') obtained by tissue Doppler imaging (TDI) is widely used to evaluate left ventricular (LV) diastolic function based on the assumption that it reflects myocardial relaxation in the long-axis direction. In this study, we aimed to determine whether or not e' truly reflects early diastolic longitudinal myocardial relaxation, and which is the most useful for evaluating LV diastolic function among e' measured at the interventricular-septal annulus (IS-e'), that measured at the lateral annulus (LW-e') or their mean value (M-e'). Methods and results: IS-e', LW-e', and M-e' were measured using colour TDI in 15 patients with hypertrophic cardiomyopathy, 13 patients with hypertension and 19 control subjects. Using two-dimensional speckle tracking imaging, early diastolic myocardial strain rates (SR_[E]) were measured for the IS (IS-SR_[E]), LW(LW-SR_[E]) and entire LV myocardium (G-SR_[E]). IS-e' was excellently correlated with IS-SR_[E] (r = 0.90, P < 0.001); the correlation was better than that between LW-e' and LW-SR_[E] (r = 0.75, P < 0.001). IS-e' and M-e' were well correlated with G-SR_[E] (r = 0.88, P < 0.001 and r = 0.86, P < 0.001, respectively) and with LV early diastolic flow propagation velocity (r = 0.77, P < 0.001 and r = 0.78, P < 0.001, respectively). The correlations of LW-e' to G-SR_[E] (r = 0.80, P < 0.001) and flow propagation velocity (r = 0.75, P < 0.001) did not reach this level. Conclusion: IS-e' well reflected LV longitudinal myocardial relaxation and LV diastolic function, and was found to be more useful in evaluating LV diastolic function than LW-e'.
Rights: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in European Heart Journal, Cardiovascular Imaging following peer review. The definitive publisher-authenticated version Eur J Echocardiogr (2011) 12(12): 917-923 is available online at:
Type: article (author version)
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岡田 一範

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