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TRIM45 negatively regulates NF-κB-mediated transcription and suppresses cell proliferation
| Title: | TRIM45 negatively regulates NF-κB-mediated transcription and suppresses cell proliferation |
| Authors: | Shibata, Mio Browse this author | | Sato, Tomonobu Browse this author | | Nukiwa, Ryota Browse this author | | Ariga, Tadashi Browse this author →KAKEN DB | | Hatakeyama, Shigetsugu Browse this author →KAKEN DB |
| Keywords: | TRIM45 | | NF-κB | | MAPK | | TNFα | | Cell proliferation |
| Issue Date: | 22-Jun-2012 |
| Publisher: | Elsevier |
| Journal Title: | Biochemical and Biophysical Research Communications |
| Volume: | 423 |
| Issue: | 1 |
| Start Page: | 104 |
| End Page: | 109 |
| Publisher DOI: | 10.1016/j.bbrc.2012.05.090 |
| PMID: | 22634006 |
| Abstract: | The NF-κB signaling pathway plays an important role in cell survival, immunity, inflammation, carcinogenesis, and organogenesis. Activation of NF-κB is regulated by several posttranslational modifications including phosphorylation, neddylation and ubiquitination. The NF-κB signaling pathway is activated by two distinct signaling mechanisms and is strictly modulated by the ubiquitin-proteasome system. It has been reported that overexpression of TRIM45, one of the TRIM family ubiquitin ligases, suppresses transcriptional activities of Elk-1 and AP-1, which are targets of the MAPK signaling pathway. In this study, we showed that TRIM45 also negatively regulates TNFα-induced NF-κB-mediated transcription by a luciferase reporter assay and that TRIM45 lacking a RING domain also has an activity to inhibit the NF-κB signal. Moreover, we found that TRIM45 overexpression suppresses cell growth. These findings suggest that TRIM45 acts as a repressor for the NF-κB signal and regulates cell growth. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/50062 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 畠山 鎮次
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