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TRIM45 negatively regulates NF-κB-mediated transcription and suppresses cell proliferation

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Title: TRIM45 negatively regulates NF-κB-mediated transcription and suppresses cell proliferation
Authors: Shibata, Mio Browse this author
Sato, Tomonobu Browse this author
Nukiwa, Ryota Browse this author
Ariga, Tadashi Browse this author →KAKEN DB
Hatakeyama, Shigetsugu Browse this author →KAKEN DB
Keywords: TRIM45
NF-κB
MAPK
TNFα
Cell proliferation
Issue Date: 22-Jun-2012
Publisher: Elsevier
Journal Title: Biochemical and Biophysical Research Communications
Volume: 423
Issue: 1
Start Page: 104
End Page: 109
Publisher DOI: 10.1016/j.bbrc.2012.05.090
PMID: 22634006
Abstract: The NF-κB signaling pathway plays an important role in cell survival, immunity, inflammation, carcinogenesis, and organogenesis. Activation of NF-κB is regulated by several posttranslational modifications including phosphorylation, neddylation and ubiquitination. The NF-κB signaling pathway is activated by two distinct signaling mechanisms and is strictly modulated by the ubiquitin-proteasome system. It has been reported that overexpression of TRIM45, one of the TRIM family ubiquitin ligases, suppresses transcriptional activities of Elk-1 and AP-1, which are targets of the MAPK signaling pathway. In this study, we showed that TRIM45 also negatively regulates TNFα-induced NF-κB-mediated transcription by a luciferase reporter assay and that TRIM45 lacking a RING domain also has an activity to inhibit the NF-κB signal. Moreover, we found that TRIM45 overexpression suppresses cell growth. These findings suggest that TRIM45 acts as a repressor for the NF-κB signal and regulates cell growth.
Type: article (author version)
URI: http://hdl.handle.net/2115/50062
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 畠山 鎮次

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