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Aldehyde oxidase 1 gene is regulated by Nrf2 pathway

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Title: Aldehyde oxidase 1 gene is regulated by Nrf2 pathway
Authors: Maeda, Kenichiro Browse this author
Ohno, Takashi Browse this author
Igarashi, Shizuka Browse this author
Yoshimura, Takaaki Browse this author
Yamashiro, Koji Browse this author
Sakai, Masaharu Browse this author →KAKEN DB
Keywords: Aldehyde oxidase 1
Nrf2-Small Maf heterodimer
Antioxidant responsive element (ARE)
Drug metabolism
Issue Date: 1-Sep-2012
Publisher: Elsevier B.V.
Journal Title: Gene
Volume: 505
Issue: 2
Start Page: 374
End Page: 378
Publisher DOI: 10.1016/j.gene.2012.06.010
PMID: 22705828
Abstract: Aldehyde oxidase is a member of the molybd-flavo enzyme family that catalyzes the hydroxylation of heterocycles and the oxidation of aldehydes into corresponding carboxylic acids. Aldehyde oxidase-1 (AOX1) is highly expressed in liver and is involved in the oxidation of a variety of aldehydes and nitrogenous heterocyclic compounds, including anti-cancer and immunosuppressive drugs. However, the physiological substrates of AOX1 have not been identified, and it was unknown how the expression of AOX1 is regulated. Here, we found that the AOX1 gene is regulated by the Nrf2 pathway. Two Nrf2 binding consensus elements (anti-oxidant responsive element, ARE) are located in the 5' upstream region of the rat AOX1 gene. Molecular analyses using reporter transfection analysis, EMSA, and ChIP analysis show that Nrf2 binds to and strongly activates the rat AOX1 gene.
Type: article (author version)
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 酒井 正春

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