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The chicken 2'-5' oligoadenylate synthetase A inhibits the replication of West Nile Virus

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Title: The chicken 2'-5' oligoadenylate synthetase A inhibits the replication of West Nile Virus
Authors: Tag-El-Din-Hassan, Hassan T. Browse this author
Sasaki, Nobuya Browse this author →KAKEN DB
Moritoh, Kanako Browse this author
Torigoe, Daisuke Browse this author
Maeda, Akihiko Browse this author
Agui, Takashi Browse this author →KAKEN DB
Keywords: West Nile virus
oligoadenylate synthetase
chicken OASL
mouse Oas1b
virus replicon
Issue Date: Aug-2012
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 60
Issue: 2&3
Start Page: 95
End Page: 103
Abstract: West Nile virus (WNV) is a pathogen to cause West Nile encephalitis when the infection occurs in the brain. Previous studies in mice identified the 2'-5' oligoadenylate synthetase 1b (Oas1b) gene as a determining factor for resistance to WNV infection. In addition, it has been suggested that human OAS1 and OASL are associated with the resistance to the WNV infection. WNV is maintained in nature through a complex life cycle involving wild birds and mosquitoes. Birds are not only susceptible to the WNV, but also act as reservoir hosts, thus participating in the spread of the disease. It has previously been reported that chicken OASL possesses the oligoadenylate synthetase activity. However, until now the antiviral activity of chicken OASL has not been determined. In this study, we investigated the putative antiviral activity of chicken OASL by ectopic expression of this enzyme in mammalian cells and then infecting these cells with WNV replicon. We demonstrate that chicken OASL has an antiviral activity against the WNV. This is the first report to show that chicken OASL is associated with the resistance to the WNV infection.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 60, Number 2&3

Submitter: 獣医学部図書室

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