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Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner

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Title: Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner
Authors: Koizumi, Shin-ichi Browse this author
Masuko, Kazutaka Browse this author
Wakita, Daiko Browse this author
Tanaka, Sachi Browse this author
Mitamura, Rieko Browse this author
Kato, Yoshihiro Browse this author
Tabata, Homare Browse this author
Nakahara, Masahiro Browse this author
Kitamura, Hidemitsu Browse this author →KAKEN DB
Nishimura, Takashi Browse this author →KAKEN DB
Keywords: Dendritic cells
Toll-like receptor
Adjuvant
Cytotoxic T lymphocytes
Type-1 immunity
Cancer immunotherapy
Issue Date: Mar-2012
Publisher: Elsevier
Journal Title: Cellular Immunology
Volume: 276
Issue: 1-2
Start Page: 153
End Page: 161
Publisher DOI: 10.1016/j.cellimm.2012.05.002
PMID: 22677561
Abstract: Type-1 immunity plays a crucial role in host defense against various tumors and infectious diseases. Here, we first demonstrated that extract of Larix Leptolepis (ELL), one of the most popular timbers at Hokkaido area in Japan, strongly activated Type-1 immunity. ELL induced production of Type-1 cytokines such as IL-12 and TNF-α from bone marrow-derived dendritic cells (BMDCs) in TLR2- and TLR4-dependent manner and remarkably up-regulated the expression of MHC and co-stimulatory molecules. In addition, antigen-specific CTLs were significantly augmented by the combined administration of ELL, antigen and BMDCs. Finally, we revealed that combination therapy using ELL, antigen and BMDCs significantly inhibited the growth of established tumor in mouse model. Thus, these findings suggested that ELL would be a novel adjuvant for inducing an activation of Type-1-dependent immunity including activation of BMDCs and induction of tumor-specific CTLs, which is applicable to the therapy of cancer and infectious diseases.
Type: article (author version)
URI: http://hdl.handle.net/2115/50107
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 西村 孝司

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