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Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner
| Title: | Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner |
| Authors: | Koizumi, Shin-ichi Browse this author | | Masuko, Kazutaka Browse this author | | Wakita, Daiko Browse this author | | Tanaka, Sachi Browse this author | | Mitamura, Rieko Browse this author | | Kato, Yoshihiro Browse this author | | Tabata, Homare Browse this author | | Nakahara, Masahiro Browse this author | | Kitamura, Hidemitsu Browse this author →KAKEN DB | | Nishimura, Takashi Browse this author →KAKEN DB |
| Keywords: | Dendritic cells | | Toll-like receptor | | Adjuvant | | Cytotoxic T lymphocytes | | Type-1 immunity | | Cancer immunotherapy |
| Issue Date: | Mar-2012 |
| Publisher: | Elsevier |
| Journal Title: | Cellular Immunology |
| Volume: | 276 |
| Issue: | 1-2 |
| Start Page: | 153 |
| End Page: | 161 |
| Publisher DOI: | 10.1016/j.cellimm.2012.05.002 |
| PMID: | 22677561 |
| Abstract: | Type-1 immunity plays a crucial role in host defense against various tumors and infectious diseases. Here, we first demonstrated that extract of Larix Leptolepis (ELL), one of the most popular timbers at Hokkaido area in Japan, strongly activated Type-1 immunity. ELL induced production of Type-1 cytokines such as IL-12 and TNF-α from bone marrow-derived dendritic cells (BMDCs) in TLR2- and TLR4-dependent manner and remarkably up-regulated the expression of MHC and co-stimulatory molecules. In addition, antigen-specific CTLs were significantly augmented by the combined administration of ELL, antigen and BMDCs. Finally, we revealed that combination therapy using ELL, antigen and BMDCs significantly inhibited the growth of established tumor in mouse model. Thus, these findings suggested that ELL would be a novel adjuvant for inducing an activation of Type-1-dependent immunity including activation of BMDCs and induction of tumor-specific CTLs, which is applicable to the therapy of cancer and infectious diseases. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/50107 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 西村 孝司
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