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Dynamic 11C-methionine PET analysis has an additional value for differentiating malignant tumors from granulomas : an experimental study using small animal PET

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Title: Dynamic 11C-methionine PET analysis has an additional value for differentiating malignant tumors from granulomas : an experimental study using small animal PET
Authors: Zhao, Songji Browse this author →KAKEN DB
Kuge, Yuji Browse this author →KAKEN DB
Yi, Min Browse this author
Zhao, Yan Browse this author
Hatano, Toshiyuki Browse this author
Magota, Keiichi Browse this author →KAKEN DB
Nishijima, Ken-ichi Browse this author
Kohanawa, Masashi Browse this author →KAKEN DB
Tamaki, Nagara Browse this author →KAKEN DB
Keywords: Dynamic 11C-MET PET
Granuloma
Inflammation
Tumor
Rat
Issue Date: Oct-2011
Publisher: Springer Berlin / Heidelberg
Journal Title: European Journal of Nuclear Medicine and Molecular Imaging
Volume: 38
Issue: 10
Start Page: 1876
End Page: 1886
Publisher DOI: 10.1007/s00259-011-1865-2
PMID: 21732106
Abstract: Purpose: We evaluated whether the dynamic profile of 11C-MET may have an additional value in differentiating malignant tumors from granulomas in experimental rat models by small animal PET. Methods: Rhodococcus aurantiacus and allogenic rat C6-glioma cells were inoculated respectively into the right and left calf muscles to generate a rat model bearing both granulomas and tumors (n = 6). Ten days after the inoculations, dynamic 11C-MET PET was performed by small-animal PET up to 120 min after injection of 11C-MET. The next day, after overnight fasting, the rats were injected with 18F-FDG, and dynamic 18F-FDG PET was performed up to 180 min. The time-activity curves, static images, and mean standardized uptake value (SUV) in the lesions were calculated. Results: 11C-MET uptake in the granuloma showed a slow exponential clearance after an initial distribution, while the uptake in the tumor gradually increased with time. The dynamic pattern of 11C-MET uptake in the granuloma was significantly different from that in the tumor (p < 0.001). In the static analysis of 11C-MET, visual assessment and SUV analysis could not differentiate the tumor from the granuloma in all cases, although the mean SUV in the granuloma (1.48 ± 0.09) was significantly lower than that in the tumor (1.72 ± 0.18, p < 0.01). The dynamic patterns, static images, and mean SUVs of 18F-FDG in the granuloma were similar to those in the tumor (p = NS). Conclusions: Dynamic 11C-MET PET has an additional value for differentiating malignant tumors from granulomatous lesions, which deserve further elucidation in clinical settings.
Rights: The original publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/50146
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 趙 松吉

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