| Title: | Dynamic 11C-methionine PET analysis has an additional value for differentiating malignant tumors from granulomas : an experimental study using small animal PET |
| Authors: | Zhao, Songji Browse this author →KAKEN DB |
| Kuge, Yuji Browse this author →KAKEN DB |
| Yi, Min Browse this author |
| Zhao, Yan Browse this author |
| Hatano, Toshiyuki Browse this author |
| Magota, Keiichi Browse this author →KAKEN DB |
| Nishijima, Ken-ichi Browse this author |
| Kohanawa, Masashi Browse this author →KAKEN DB |
| Tamaki, Nagara Browse this author →KAKEN DB |
| Keywords: | Dynamic 11C-MET PET |
| Granuloma |
| Inflammation |
| Tumor |
| Rat |
| Issue Date: | Oct-2011 |
| Publisher: | Springer Berlin / Heidelberg |
| Journal Title: | European Journal of Nuclear Medicine and Molecular Imaging |
| Volume: | 38 |
| Issue: | 10 |
| Start Page: | 1876 |
| End Page: | 1886 |
| Publisher DOI: | 10.1007/s00259-011-1865-2 |
| PMID: | 21732106 |
| Abstract: | Purpose: We evaluated whether the dynamic profile of 11C-MET may have an additional value in differentiating malignant tumors from granulomas in experimental rat models by small animal PET. Methods: Rhodococcus aurantiacus and allogenic rat C6-glioma cells were inoculated respectively into the right and left calf muscles to generate a rat model bearing both granulomas and tumors (n = 6). Ten days after the inoculations, dynamic 11C-MET PET was performed by small-animal PET up to 120 min after injection of 11C-MET. The next day, after overnight fasting, the rats were injected with 18F-FDG, and dynamic 18F-FDG PET was performed up to 180 min. The time-activity curves, static images, and mean standardized uptake value (SUV) in the lesions were calculated. Results: 11C-MET uptake in the granuloma showed a slow exponential clearance after an initial distribution, while the uptake in the tumor gradually increased with time. The dynamic pattern of 11C-MET uptake in the granuloma was significantly different from that in the tumor (p < 0.001). In the static analysis of 11C-MET, visual assessment and SUV analysis could not differentiate the tumor from the granuloma in all cases, although the mean SUV in the granuloma (1.48 ± 0.09) was significantly lower than that in the tumor (1.72 ± 0.18, p < 0.01). The dynamic patterns, static images, and mean SUVs of 18F-FDG in the granuloma were similar to those in the tumor (p = NS). Conclusions: Dynamic 11C-MET PET has an additional value for differentiating malignant tumors from granulomatous lesions, which deserve further elucidation in clinical settings. |
| Rights: | The original publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/50146 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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