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Identification and expression analysis of the genes involved in serotonin biosynthesis and transduction in the field cricket Gryllus bimaculatus

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Title: Identification and expression analysis of the genes involved in serotonin biosynthesis and transduction in the field cricket Gryllus bimaculatus
Authors: Watanabe, Takayuki Browse this author
Sadamoto, Hisayo Browse this author
Aonuma, Hitoshi Browse this author →KAKEN DB
Keywords: serotonin
tryptophan hydroxylase
phenylalanine-tryptophan hydroxylase
aromatic L-amino acid decarboxylase
serotonin receptors
Gryllus bimaculatus
Issue Date: Oct-2011
Publisher: Wiley-Blackwell
Journal Title: Insect Molecular Biology
Volume: 20
Issue: 5
Start Page: 619
End Page: 635
Publisher DOI: 10.1111/j.1365-2583.2011.01093.x
PMID: 21699597
Abstract: Serotonin (5-HT) modulates various aspects of behaviours such as aggressive behaviour and circadian behaviour in the cricket. To elucidate the molecular basis of the cricket 5-HT system, we identified 5-HT-related genes in the field cricket Gryllus bimaculatus DeGeer. Complementary DNA of tryptophan hydroxylase (TRH) and phenylalanine-tryptophan hydroxylase (TPH) which convert tryptophan into 5-hydroxy-L-tryptophan (5-HTP), and that of aromatic L-amino acid decarboxylase (AADC) which converts 5-HTP into 5-HT were isolated from a cricket brain cDNA library. In addition, four 5-HT receptor genes (5-HT_[1A], 5-HT_[1B], 5-HT_[2α], and 5-HT7) were identified. Expression analysis of TRH and TPH, which are selectively involved in neuronal and peripheral 5-HT synthesis in Drosophila, suggested that two 5-HT synthesis pathways co-exist in the cricket neuronal tissues. The four of 5-HT receptor genes were expressed in various tissues at differential expression levels, suggesting that the 5-HT system is widely distributed in the cricket.
Rights: The definitive version is available at
Type: article (author version)
Appears in Collections:電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 青沼 仁志

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