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Utility and limitations of PHQ-9 in a clinic specializing in psychiatric care

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/50160

Title: Utility and limitations of PHQ-9 in a clinic specializing in psychiatric care
Authors: Inoue, Takeshi Browse this author →KAKEN DB
Tanaka, Teruaki Browse this author
Nakagawa, Shin Browse this author →KAKEN DB
Nakato, Yasuya Browse this author
Kameyama, Rie Browse this author
Boku, Shuken Browse this author →KAKEN DB
Toda, Hiroyuki Browse this author
Kurita, Tsugiko Browse this author
Koyama, Tsukasa Browse this author →KAKEN DB
Issue Date: 3-Jul-2012
Publisher: BioMed Central
Journal Title: BMC Psychiatry
Volume: 12
Start Page: 73
Publisher DOI: 10.1186/1471-244X-12-73
Abstract: Background: The Patient Health Questionnaire-9 (PHQ-9), despite its excellent reliability and validity in primary care, has not been examined for administration to psychiatric patients. This study assesses the accuracy of PHQ-9 in screening for major depressive episode and in diagnosing major depressive episode in patients of a psychiatric specialty clinic. Methods: We compared operational characteristics of PHQ-9 as a screening and diagnostic instrument to DSM-IV-TR diagnosis by a trained psychiatrist as a reference standard. The reference criteria were "current major depressive episode" or "current major depressive episode with major depressive disorder". PHQ-9 was used with two thresholds: diagnostic algorithm and summary scores (PHQ-9 ≥ 10). The optimal cut-off points of PHQ-9 summary scores were analyzed using a receiver operational characteristics (ROC) curve. Results: For "current major depressive episode", PHQ-9 showed high sensitivity and high negative predictive value at both thresholds, but its specificity and positive predictive value were low. For "current major depressive episode with major depressive disorder", PHQ-9 also showed high sensitivity and high negative predictive value at both thresholds, but the positive predictive value decreased more than that for "current major depressive episode". The ROC analysis showed the optimal cut-off score of 13/14 for "current major depressive episode". Conclusions: PHQ-9 is useful for screening, but not for diagnosis of "current major depressive episode" in a psychiatric specialty clinic.
Rights: http://creativecommons.org/licenses/by/2.0/
Type: article
URI: http://hdl.handle.net/2115/50160
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 井上 猛

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