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Synbiotic therapy reduces the pathological gram-negative rods caused by an increased acetic Acid concentration in the gut.

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Title: Synbiotic therapy reduces the pathological gram-negative rods caused by an increased acetic Acid concentration in the gut.
Authors: Hayakawa, Mineji Browse this author →KAKEN DB
Asahara, Takashi Browse this author
Ishitani, Toshiteru Browse this author
Okamura, Atsushi Browse this author
Nomoto, Koji Browse this author
Gando, Satoshi Browse this author →KAKEN DB
Keywords: Pseudomonas
Enteral nutrition
Ventilator-associated pneumonia
Critical illness
Issue Date: Oct-2012
Publisher: Springer
Journal Title: Digestive Diseases and Sciences
Volume: 57
Issue: 10
Start Page: 2642
End Page: 2649
Publisher DOI: 10.1007/s10620-012-2201-9
PMID: 22576712
Abstract: BACKGROUND: The mechanisms for the improvement of the gut flora and the intestinal environment by synbiotic therapy are unclear. AIMS: This study evaluated the changes in the gut flora and the intestinal environment after synbiotic therapy, and tried to clarify the mechanisms by which synbiotic therapy reduces pathological bacteria in the gut. METHODS: A total of 47 enteral feeding patients with long-term mechanical ventilation support were enrolled in the study. Patients were randomly assigned to synbiotic and control groups, at a two to one ratio. Patients in the synbiotic group were administrated Lactobacillus, Bifidobacterium, and galactooligosaccharides as synbiotics for 8 weeks. RESULTS: The characteristics of the patients were not significantly different between the control (n = 16) and synbiotic (n = 31) groups. In the synbiotic group, the counts of Bifidobacterium and Lactobacillus in the gut increased significantly to 100 times the initial level following synbiotic treatment. The acetic acid concentration increased (71.1 ± 15.9 vs. 46.8 ± 24.1 μmol/g) and pH decreased in the gut in comparison with the control group. The concentration of acetic acid in the gut increased in proportion to the Bifidobacterium counts. The counts of pathological gram-negative rod decreased significantly to one-tenth of the initial level in inverse proportion to the Bifidobacterium counts. Furthermore, the amount of Pseudomonas aeruginosa in the lower respiratory tract decreased significantly after synbiotic therapy compared to the controls. CONCLUSION: Synbiotic therapy reduces the pathological Gram-negative rods by increasing the acetic acid concentration in association with an increased counts of Bifidobacterium.
Rights: The final publication is available at
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 早川 峰司

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