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Substrate-like water soluble lipase inhibitors from Filipendula kamtschatica

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Title: Substrate-like water soluble lipase inhibitors from Filipendula kamtschatica
Authors: Kato, Eisuke Browse this author →KAKEN DB
Yama, Michitsugu Browse this author
Nakagomi, Ryo Browse this author
Shibata, Toshiro Browse this author
Hosokawa, Keizo Browse this author
Kawabata, Jun Browse this author →KAKEN DB
Keywords: Filipendula kamtschatica
Pancreatic lipase inhibitor
Traditional medicine
Issue Date: 15-Oct-2012
Publisher: Elsevier
Journal Title: Bioorganic & Medicinal Chemistry Letters
Volume: 22
Issue: 20
Start Page: 6410
End Page: 6412
Publisher DOI: 10.1016/j.bmcl.2012.08.055
PMID: 22995617
Abstract: Filipendula kamtschatica is a plant utilized as a traditional medicine by Ainu people in Japan, but its chemical constituents are not much studied. Pancreatic lipase inhibitors are a promising tool for the treatment of obesity. We searched for natural lipase inhibitors from F. kamtschatica and two new compounds were isolated along with the known flavonoid glycoside. The structure elucidation of new compounds revealed these two to be 2-O-caffeoyl-4-O-galloyl-L-threonic acid and 3-O-caffeoyl-4-O-galloyl-L-threonic acid, which can be recognized as a pancreatic lipase's substrate-like structure. The isolated compounds all showed an inhibitory activity against porcine pancreatic lipase and one of the isomer, 3-O-caffeoyl-4-O-galloyl-L-threonic acid, possessed the most potent activity with IC50 value showing an order lower value compared to others. The substrate-like structure of the new compounds seemed to be important for their activity.
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

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