Quantitative Determination of Click Reaction in the Presence of Glycine Derivatives and in Dilute Solution


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Title:	Quantitative Determination of Click Reaction in the Presence of Glycine Derivatives and in Dilute Solution
Authors:	Ogasawara, Yui Browse this author
	Yuta, Murai Browse this author
	Yasuko, Sakihama Browse this author →KAKEN DB
	Yasuyuki, Hashidoko Browse this author →KAKEN DB
	Makoto, Hashimoto Browse this author →KAKEN DB
Keywords:	Click Chemistry
	Quantitative Determination
	Propargylglycine
	Cu(I)
	Buffer
Issue Date:	Nov-2012
Publisher:	Scientific Research Publishing
Journal Title:	International Journal of Organic Chemistry
Volume:	02
Issue:	03
Start Page:	302
End Page:	304
Publisher DOI:	10.4236/ijoc.2012.223041
Abstract:	The click reaction is one of the latest techniques for the functional analysis of bioactive compounds and the analysis makes novel concepts and strategies for medicinal chemistry. N-methylated glycine derivatives have inhibitory activity for the click reaction in direct Cu(I) system because of decrease of Cu(I) concentration. The Cu(I) concentration recovered effectively by sodium ascorbate. Quantitative determination of click reaction at various ligand concentrations revealed that the decrease in reaction yields was observed in a substrate concentration-dependent manner.
Type:	article (author version)
URI:	http://hdl.handle.net/2115/50765
Appears in Collections:	農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 橋本誠

OAI-PMH ( junii2 , jpcoar_1.0 )

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