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Effective Friedel-Crafts Acylation of Biotin Acid Chloride in Trifluoromethanesulfonic Acid

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Title: Effective Friedel-Crafts Acylation of Biotin Acid Chloride in Trifluoromethanesulfonic Acid
Authors: MUTO, Yasuyuki Browse this author
MURAI, Yuta Browse this author
SAKIHAMA, Yasuko Browse this author →KAKEN DB
HASHIDOKO, Yasuyuki Browse this author →KAKEN DB
HASHIMOTO, Makoto Browse this author →KAKEN DB
Keywords: biotin
Friedel-Crafts acylation
triflic acid
2-(4'-hydroxyphenylazo)benzoic acid
Issue Date: Nov-2012
Publisher: 日本農芸化学会
Journal Title: Bioscience, Biotechnology, and Biochemistry
Volume: 76
Issue: 11
Start Page: 2162
End Page: 2164
Publisher DOI: 10.1271/bbb.120553
PMID: 23132579
Abstract: Biotin is one of the most useful tags in (bio)analytical science due to its specific interaction with avidin, but is not easy to convert because of its low solubility in most solvents. Friedel-Crafts acylation of biotin acid chloride in triflic acid was examined, and the synthesized derivatives had stronger affinity to avidin than biotin in a binding assay using 2-(4'-hydroxyphenylazo)benzoic acid.
Type: article
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 橋本 誠

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