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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Effective Friedel-Crafts Acylation of Biotin Acid Chloride in Trifluoromethanesulfonic Acid
| Title: | Effective Friedel-Crafts Acylation of Biotin Acid Chloride in Trifluoromethanesulfonic Acid |
| Authors: | MUTO, Yasuyuki Browse this author | | MURAI, Yuta Browse this author | | SAKIHAMA, Yasuko Browse this author →KAKEN DB | | HASHIDOKO, Yasuyuki Browse this author →KAKEN DB | | HASHIMOTO, Makoto Browse this author →KAKEN DB |
| Keywords: | biotin | | avidin | | Friedel-Crafts acylation | | triflic acid | | 2-(4'-hydroxyphenylazo)benzoic acid |
| Issue Date: | Nov-2012 |
| Publisher: | 日本農芸化学会 |
| Journal Title: | Bioscience, Biotechnology, and Biochemistry |
| Volume: | 76 |
| Issue: | 11 |
| Start Page: | 2162 |
| End Page: | 2164 |
| Publisher DOI: | 10.1271/bbb.120553 |
| PMID: | 23132579 |
| Abstract: | Biotin is one of the most useful tags in (bio)analytical science due to its specific interaction with avidin, but is not easy to convert because of its low solubility in most solvents. Friedel-Crafts acylation of biotin acid chloride in triflic acid was examined, and the synthesized derivatives had stronger affinity to avidin than biotin in a binding assay using 2-(4'-hydroxyphenylazo)benzoic acid. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/50767 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 橋本 誠
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