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Ovarian cysts in MRL/MpJ mice are derived from the extraovarian rete : a developmental study

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Title: Ovarian cysts in MRL/MpJ mice are derived from the extraovarian rete : a developmental study
Authors: Lee, Shin-Hyo Browse this author
Ichii, Osamu Browse this author →KAKEN DB
Otsuka, Saori Browse this author →KAKEN DB
Elewa, Yaser Hosney Browse this author →ORCID
Namiki, Yuka Browse this author →KAKEN DB
Hashimoto, Yoshiharu Browse this author →KAKEN DB
Kon, Yasuhiro Browse this author →KAKEN DB
Keywords: mesonephric tubules
MRL/MpJ mice
ovarian cysts
rete ovarii
Issue Date: Dec-2011
Publisher: Blackwell Publishing
Journal Title: Journal of Anatomy
Volume: 219
Issue: 6
Start Page: 743
End Page: 755
Publisher DOI: 10.1111/j.1469-7580.2011.01431.x
Abstract: MRL/MpJ (MRL) mice, commonly used as a model for autoimmune disease, have a high frequency of ovarian cysts originating from the rete ovarii. In the present study, to clarify how the rete ovarii, which are remnants of mesonephric tubules during embryogenesis, progress to cystic formation with aging, the morphology of MRL rete ovarii was analyzed and compared to that of normal C57BL/6N (B6) mice. In B6 mice, the rete ovarii consisted of a series of tubules, including the extraovarian rete (ER), the connecting rete (CR), and the intraovarian rete (IR), based on their location. Although the ER of B6 mice was composed of highly convoluted tubules lined by both ciliated and non-ciliated epithelium, the tubules in the CR and IR had only non-ciliated cells. In MRL mice, dilations of the rete ovarii initiated from the IR rather than the ER or CR. Although the histological types of cells lining the lumen of the rete ovarii were the same as those in B6 mice, the ER in MRL mice showed a variety in morphology. In particular, the connections between the ER and ovary tended to disappear with increasing age and the development of ovarian cysts. Furthermore, the epithelium lining large ovarian cysts in MRL mice had ciliated cells forming the cluster. From these findings, it was suggested that cystic changes of the rete ovarii in MRL mice were caused by the dilations of the IR with invasion of the ER and CR into the ovarian medulla. These data provide new pathological mechanisms for ovarian cyst formation.
Rights: The definitive version is available at
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 昆 泰寛

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