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PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/50788

Title: PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker
Authors: Yuzawa, Sayaka Browse this author
Kano, Mitsunobu R. Browse this author
Einama, Takahiro Browse this author
Nishihara, Hiroshi Browse this author
Keywords: Pancreatic adenocarcinoma
Tumor stroma
Prognosis
PDGFRβ
SMA
Issue Date: Dec-2012
Publisher: Springer US
Journal Title: Medical Oncology
Volume: 29
Issue: 4
Start Page: 2824
End Page: 2830
Publisher DOI: 10.1007/s12032-012-0193-0
Abstract: Pancreatic adenocarcinoma is a lethal disease that often develops a desmoplastic reaction in tumor stroma. In general, desmoplasia is thought to promote tumor growth. However, its molecular pathology and prognostic potential have not been fully investigated. Here, we investigate 26 cases of pancreatic ductal adenocarcinoma and examine the clinicopathological association between survival and expression levels of several molecular markers for stromal cells. These include alpha smooth muscle actin (SMA) and platelet-derived growth factor (PDGF) receptor β (PDGFRβ). Both are markers of activated fibroblasts or pancreatic stellate cells (PSCs) that play an important role in desmoplasia. The staining patterns of both molecular markers were not uniform so we categorized them into 3 grades (high, middle, and low) according to intensity. Interestingly, Kaplan-Meier analysis revealed that higher expression of PDGFRβ matched shorter prognosis (p = 0.0287, log-rank test) as well as lymphatic invasion and lymph node metastasis, whereas SMA did not (p = 0.6122). Our results suggest the prognostic potential of cancer stroma via PDGF-B signaling. Regulation of PDGF-B-associated signaling crosstalk between cancer cells and stroma cells, therefore, may indicate a possible therapeutic target for desmoplastic malignant tumors such as pancreatic adenocarcinoma.
Rights: The final publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/50788
Appears in Collections:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 西原 広史

 

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