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PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker
Title: | PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker |
Authors: | Yuzawa, Sayaka Browse this author | Kano, Mitsunobu R. Browse this author | Einama, Takahiro Browse this author | Nishihara, Hiroshi Browse this author →KAKEN DB |
Keywords: | Pancreatic adenocarcinoma | Tumor stroma | Prognosis | PDGFRβ | SMA |
Issue Date: | Dec-2012 |
Publisher: | Springer US |
Journal Title: | Medical Oncology |
Volume: | 29 |
Issue: | 4 |
Start Page: | 2824 |
End Page: | 2830 |
Publisher DOI: | 10.1007/s12032-012-0193-0 |
PMID: | 22403002 |
Abstract: | Pancreatic adenocarcinoma is a lethal disease that often develops a desmoplastic reaction in tumor stroma. In general, desmoplasia is thought to promote tumor growth. However, its molecular pathology and prognostic potential have not been fully investigated. Here, we investigate 26 cases of pancreatic ductal adenocarcinoma and examine the clinicopathological association between survival and expression levels of several molecular markers for stromal cells. These include alpha smooth muscle actin (SMA) and platelet-derived growth factor (PDGF) receptor β (PDGFRβ). Both are markers of activated fibroblasts or pancreatic stellate cells (PSCs) that play an important role in desmoplasia. The staining patterns of both molecular markers were not uniform so we categorized them into 3 grades (high, middle, and low) according to intensity. Interestingly, Kaplan-Meier analysis revealed that higher expression of PDGFRβ matched shorter prognosis (p = 0.0287, log-rank test) as well as lymphatic invasion and lymph node metastasis, whereas SMA did not (p = 0.6122). Our results suggest the prognostic potential of cancer stroma via PDGF-B signaling. Regulation of PDGF-B-associated signaling crosstalk between cancer cells and stroma cells, therefore, may indicate a possible therapeutic target for desmoplastic malignant tumors such as pancreatic adenocarcinoma. |
Rights: | The final publication is available at www.springerlink.com |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/50788 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 西原 広史
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