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Conjunctival lymphoma arising from reactive lymphoid hyperplasia
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| Title: | Conjunctival lymphoma arising from reactive lymphoid hyperplasia |
| Authors: | Fukuhara, Junichi Browse this author | | Kase, Satoru Browse this author →KAKEN DB | | Noda, Mika Browse this author | | Ishijima, Kan Browse this author | | Yamamoto, Teppei Browse this author | | Ishida, Susumu Browse this author →KAKEN DB |
| Keywords: | Conjunctiva | | Extra nodal marginal zone B-cell lymphoma | | Reactive lymphoid hyperplasia |
| Issue Date: | 18-Sep-2012 |
| Publisher: | BioMed Central |
| Journal Title: | World Journal of Surgical Oncology |
| Volume: | 10 |
| Start Page: | 194 |
| Publisher DOI: | 10.1186/1477-7819-10-194 |
| Abstract: | Extra nodal marginal zone B-cell lymphoma (EMZL) of the conjunctiva typically arises in the marginal zone of mucosa-associated lymphoid tissue. The pathogenesis of conjunctival EMZL remains unknown. We describe an unusual case of EMZL arising from reactive lymphoid hyperplasia (RLH) of the conjunctiva. A 35-year-old woman had fleshy salmon-pink conjunctival tumors in both eyes, oculus uterque (OU). Specimens from conjunctival tumors in the right eye, oculus dexter (OD), revealed a collection of small lymphoid cells in the stroma. Immunohistochemically, immunoglobulin (Ig) light chain restriction was not detected. In contrast, diffuse atypical lymphoid cell infiltration was noted in the left eye, oculus sinister (OS), and positive for CD20, a marker for B cells OS. The tumors were histologically diagnosed as RLH OD, and EMZL OS. PCR analysis detected IgH gene rearrangement in the joining region (JH) region OU. After 11 months, a re-biopsy specimen demonstrated EMZL based on compatible pathological and genetic findings OD, arising from RLH. This case suggests that even if the diagnosis of the conjunctival lymphoproliferative lesions is histologically benign, confirmation of the B-cell clonality by checking IgH gene rearrangement should be useful to predict the incidence of malignancy. |
| Rights: | http://creativecommons.org/licenses/by/2.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/50822 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加瀬 諭
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