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Volume 60 Number 4 >

Cytochrome P450 3A mRNA expression along goat and rat gastrointestinal tracts

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Title: Cytochrome P450 3A mRNA expression along goat and rat gastrointestinal tracts
Authors: Mureithi, Dominic Browse this author
Darwish, Wageh Sobhy Browse this author
Ikenaka, Yoshinori Browse this author
Kanja, Laetitia Browse this author
Ishizuka, Mayumi Browse this author
Keywords: Cytochrome P450 3A
Small intestine
Issue Date: Nov-2012
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 60
Issue: 4
Start Page: 205
End Page: 210
Abstract: The cytochrome P450 (CYP) 3A family is involved in the elimination processes of almost 50% of commonly used drugs. CYP3A mRNA expressions in goat and rat gastrointestinal tracts in comparison to the liver were investigated using real-time PCR. In goats, the expression of CYP3A-like mRNAs was comparatively higher in the liver than in the gastrointestinal tract. The intestinal expression of CYP3A-like mRNA showed a gradual decrease from the duodenum to the ileum. In rats, the highest CYP3A62 mRNA expression was found in the duodenum followed by the liver. This study provides insights into the contribution of CYP3A enzymes to xenobiotic metabolism, especially in small ruminants such as goats.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 60 Number 4

Submitter: 獣医学部図書室

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