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Volume 60 Number 4 >

Cytochrome P450 3A mRNA expression along goat and rat gastrointestinal tracts

獣医学部紀要60巻4号_04_Mureithi他.pdf203.68 kBPDF見る/開く

タイトル: Cytochrome P450 3A mRNA expression along goat and rat gastrointestinal tracts
著者: Mureithi, Dominic 著作を一覧する
Darwish, Wageh Sobhy 著作を一覧する
Ikenaka, Yoshinori 著作を一覧する
Kanja, Laetitia 著作を一覧する
Ishizuka, Mayumi 著作を一覧する
キーワード: Cytochrome P450 3A
Small intestine
発行日: 2012年11月
出版者: Graduate School of Veterinary Medicine, Hokkaido University
誌名: Japanese Journal of Veterinary Research
巻: 60
号: 4
開始ページ: 205
終了ページ: 210
抄録: The cytochrome P450 (CYP) 3A family is involved in the elimination processes of almost 50% of commonly used drugs. CYP3A mRNA expressions in goat and rat gastrointestinal tracts in comparison to the liver were investigated using real-time PCR. In goats, the expression of CYP3A-like mRNAs was comparatively higher in the liver than in the gastrointestinal tract. The intestinal expression of CYP3A-like mRNA showed a gradual decrease from the duodenum to the ileum. In rats, the highest CYP3A62 mRNA expression was found in the duodenum followed by the liver. This study provides insights into the contribution of CYP3A enzymes to xenobiotic metabolism, especially in small ruminants such as goats.
資料タイプ: bulletin (article)
出現コレクション:Volume 60 Number 4

提供者: 獣医学部図書室


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