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Graphical representation of the effects on tumor and OAR for determining the appropriate fractionation regimen in radiation therapy planning

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/51088

Title: Graphical representation of the effects on tumor and OAR for determining the appropriate fractionation regimen in radiation therapy planning
Authors: Mizuta, Masahiro Browse this author
Date, Hiroyuki Browse this author →KAKEN DB
Takao, Seishin Browse this author →KAKEN DB
Kishimoto, Naoki Browse this author
Sutherland, Kenneth L. Browse this author →KAKEN DB
Onimaru, Rikiya Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: radiation therapy
radiation effect
dose fractionation
organ at riskl
inear-quadratic model
Issue Date: Nov-2012
Publisher: American Association of Physicists in Medicine
Journal Title: Medical Physics
Volume: 39
Issue: 11
Start Page: 6791
End Page: 6795
Publisher DOI: 10.1118/1.4757580
PMID: 23127073
Abstract: PURPOSE: The authors propose a graphical representation of the relation between the effect on the tumor and the damage effect on an organ at risk (OAR) against the irradiation dose, as an aid for choosing an appropriate fractionation regimen. METHODS: The graphical relation is depicted by the radiation effect on the tumor E(1) versus that on an OAR E(0). By observing the features of the E(1) vs E(0) relation curve, i.e., convex or concave shape, one can judge whether multifractionation is better or not. This method is applied to the linear-quadratic model (with α and β parameters) as an example. Further, the method is extended to the general case for nonuniform dose distribution to the OAR, which is frequently seen in clinical situations. RESULTS: The criterion for selecting multi- or hypofractionation is based on the relation between the dose for the OAR and the α∕β ratio of the OAR to the tumor. It is also shown that the graphical relation enables us to estimate the final effect after multifractionated treatment by plotting a tangent line on the curve. CONCLUSIONS: The graphical representation method is of use for improving planning in radiotherapy by determining the effective fractionation scheme.
Relation: http://online.medphys.org/resource/1/mphya6/v39/i11/p6791_s1
Type: article (author version)
URI: http://hdl.handle.net/2115/51088
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 伊達 広行

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