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Replication of a microsatellite genome-wide association study of Behçet's disease in a Korean population

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Title: Replication of a microsatellite genome-wide association study of Behçet's disease in a Korean population
Authors: Horie, Yukihiro Browse this author
Meguro, Akira Browse this author
Kitaichi, Nobuyoshi Browse this author →KAKEN DB
Lee, Eun Bong Browse this author
Kanda, Atsuhiro Browse this author
Noda, Kousuke Browse this author →KAKEN DB
Song, Yeong Wook Browse this author
Park, Kyung Sook Browse this author
Namba, Kenichi Browse this author →KAKEN DB
Ota, Masao Browse this author
Inoko, Hidetoshi Browse this author
Mizuki, Nobuhisa Browse this author
Ishida, Susumu Browse this author →KAKEN DB
Ohno, Shigeaki Browse this author →KAKEN DB
Keywords: microsatellite
GWAS
Behçet's disease
replication study
HLA-B
Korean
Issue Date: Jun-2012
Publisher: Oxford University Press
Journal Title: Rheumatology
Volume: 51
Issue: 6
Start Page: 983
End Page: 986
Publisher DOI: 10.1093/rheumatology/ker444
PMID: 22258392
Abstract: Objective: Behcet disease is one of the major etiologies of uveitis causing blindness in Asian countries. A genome-wide association study identified 6 microsatellite markers as disease susceptibility loci for Japanese patients with Behcet disease. To confirm our recent results, these microsatellite markers were examined in a Korean population as a replication study. Methods: Study participants included 119 Behcet patients and 141 controls. All were enrolled in Korea. Association between the 6 reported microsatellite markers (D3S0186i, D6S0014i, D6S0032i, 536G12A, D12S0645i, and D22S0104i) and Behcet disease was analysed. HLA-B was genotyped by sequence-based typing methods. Results: A microsatellite marker located near the HLA-B region demonstrated significant association with Behcet disease (P = 0.028). The genotype and phenotype frequencies of the HLA-B*51 gene were significantly increased in patients (23.1% and 39.5%, respectively) compared with healthy controls (11.2% and 20.1%, respectively; P < 0.001). Conclusions: Microsatellite analysis revealed that the HLA-B*51 gene was strongly associated with Behcet disease in a Korean population.
Rights: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Rheumatology following peer review. The definitive publisher-authenticated version, Rheumatology (2012) 51 (6): 983-986, is available online at: http://rheumatology.oxfordjournals.org/content/51/6/983
Type: article (author version)
URI: http://hdl.handle.net/2115/51366
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 北市 伸義

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