Title: | Replication of a microsatellite genome-wide association study of Behçet's disease in a Korean population |
Authors: | Horie, Yukihiro Browse this author |
Meguro, Akira Browse this author |
Kitaichi, Nobuyoshi Browse this author →KAKEN DB |
Lee, Eun Bong Browse this author |
Kanda, Atsuhiro Browse this author |
Noda, Kousuke Browse this author →KAKEN DB |
Song, Yeong Wook Browse this author |
Park, Kyung Sook Browse this author |
Namba, Kenichi Browse this author →KAKEN DB |
Ota, Masao Browse this author |
Inoko, Hidetoshi Browse this author |
Mizuki, Nobuhisa Browse this author |
Ishida, Susumu Browse this author →KAKEN DB |
Ohno, Shigeaki Browse this author →KAKEN DB |
Keywords: | microsatellite |
GWAS |
Behçet's disease |
replication study |
HLA-B |
Korean |
Issue Date: | Jun-2012 |
Publisher: | Oxford University Press |
Journal Title: | Rheumatology |
Volume: | 51 |
Issue: | 6 |
Start Page: | 983 |
End Page: | 986 |
Publisher DOI: | 10.1093/rheumatology/ker444 |
PMID: | 22258392 |
Abstract: | Objective: Behcet disease is one of the major etiologies of uveitis causing blindness in Asian countries. A genome-wide association study identified 6 microsatellite markers as disease susceptibility loci for Japanese patients with Behcet disease. To confirm our recent results, these microsatellite markers were examined in a Korean population as a replication study. Methods: Study participants included 119 Behcet patients and 141 controls. All were enrolled in Korea. Association between the 6 reported microsatellite markers (D3S0186i, D6S0014i, D6S0032i, 536G12A, D12S0645i, and D22S0104i) and Behcet disease was analysed. HLA-B was genotyped by sequence-based typing methods. Results: A microsatellite marker located near the HLA-B region demonstrated significant association with Behcet disease (P = 0.028). The genotype and phenotype frequencies of the HLA-B*51 gene were significantly increased in patients (23.1% and 39.5%, respectively) compared with healthy controls (11.2% and 20.1%, respectively; P < 0.001). Conclusions: Microsatellite analysis revealed that the HLA-B*51 gene was strongly associated with Behcet disease in a Korean population. |
Rights: | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Rheumatology following peer review. The definitive publisher-authenticated version, Rheumatology (2012) 51 (6): 983-986, is available online at: http://rheumatology.oxfordjournals.org/content/51/6/983 |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/51366 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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