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[18F]fluoromisonidazole and a New PET System With Semiconductor Detectors and a Depth of Interaction System for Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer

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Title: [18F]fluoromisonidazole and a New PET System With Semiconductor Detectors and a Depth of Interaction System for Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer
Authors: Yasuda, Koichi Browse this author →KAKEN DB
Onimaru, Rikiya Browse this author →KAKEN DB
Okamoto, Shozo Browse this author
Shiga, Tohru Browse this author →KAKEN DB
Katoh, Norio Browse this author
Tsuchiya, Kazuhiko Browse this author
Suzuki, Ryusuke Browse this author →KAKEN DB
Takeuchi, Wataru Browse this author
Kuge, Yuji Browse this author →KAKEN DB
Tamaki, Nagara Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: radiotherapy
hypoxia
positron emission tomography
18F-fluoromisonidazole
semiconductor
Issue Date: 1-Jan-2013
Publisher: Elsevier
Journal Title: International Journal of Radiation Oncology*Biology*Physics
Volume: 85
Issue: 1
Start Page: 142
End Page: 147
Publisher DOI: 10.1016/j.ijrobp.2012.03.029
PMID: 22583608
Abstract: Purpose: The impact of a new type of positron emission tomography with semiconductor detectors (New PET) on an 18F-fluoromisonidazole (FMISO)-guided intensity-modulated radiation therapy (IMRT) plan was investigated by comparing the plan with the use of a state-of-the-art PET/computed tomography system (PET/CT) in nasopharyngeal cancer (NPC) patients. Methods and Materials: Twenty-four patients with non-NPC malignant tumors (control group) and 16 patients with NPC were subjected to FMISO-PET. The threshold of the tumor-to-muscle (T/M) ratio in each PET scan was calculated. The hypoxic volume within the gross tumor volume was determined using each PET ([NewPET]GTVh and [PET/CT]GTVh, respectively). Dose-escalation IMRT plans prescribing 84Gy to each GTVh were carried out. Results: The threshold of the T/M ratio was calculated to be 1.35 for New PET and 1.23 for PET/CT. The mean volume of [NewPET]GTVh was significantly smaller than that of [PET/CT]GTVh (1.5±1.6cc vs. 4.7±4.6cc, respectively, P =0.0020). The dose-escalation IMRT plans using New PET were superior in dose distribution to those using PET/CT. Dose escalation was possible in all 10 New PET-guided plans but not in one PET/CT-guided plan, because the threshold dose to the brainstem was exceeded. Conclusion: New PET was suggested to be useful for accurate dose escalation in FMISO-guided IMRT for patients with NPC.
Type: article (author version)
URI: http://hdl.handle.net/2115/51373
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 安田 耕一

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