| Title: | Identification of genetic loci affecting the establishment and development of Echinococcus multilocularis larvae in mice |
| Authors: | Nakao, Ryo Browse this author →KAKEN DB |
| Kameda, Yayoi Browse this author |
| Kouguchi, Hirokazu Browse this author →KAKEN DB |
| Matsumoto, Jun Browse this author |
| Dang, Zhisheng Browse this author |
| Simon, Ayo Yila Browse this author |
| Torigoe, Daisuke Browse this author |
| Sasaki, Nobuya Browse this author →KAKEN DB |
| Oku, Yuzaburo Browse this author →KAKEN DB |
| Sugimoto, Chiriro Browse this author |
| Agui, Takashi Browse this author →KAKEN DB |
| Yagi, Kinpei Browse this author |
| Keywords: | Echinococcus multilocularis |
| Alveolar echinococcosis |
| Zoonosis |
| QTL |
| Cyst |
| Protoscolex |
| Emcys1 |
| Empsc1 |
| Issue Date: | Sep-2011 |
| Publisher: | Elsevier |
| Journal Title: | International Journal for Parasitology |
| Volume: | 41 |
| Issue: | 11 |
| Start Page: | 1121 |
| End Page: | 1128 |
| Publisher DOI: | 10.1016/j.ijpara.2011.06.007 |
| PMID: | 21835179 |
| Abstract: | Alveolar echinococcosis (AE) is a severe hepatic disorder caused by larval infection by the fox tapeworm Echinococcus multilocularis. The course of parasitic development and host reactions are known to vary significantly among host species, and even among different inbred strains of mice. As reported previously, after oral administration of parasite eggs, DBA/2 (D2) mice showed a higher rate of cyst establishment and more advanced protoscolex development in the liver than C57BL/6 (B6) mice. These findings strongly suggest that the outcome of AE is affected by host genetic factor(s). In the present study, the genetic basis of such strain-specific differences in susceptibility/resistance to AE in murine models was studied by whole-genome scanning for quantitative trait loci (QTLs) using a backcross of (B6 × D2)F1 and D2 mice with varying susceptibility to E. multilocularis infection. For cyst establishment, genome linkage analysis identified one suggestive and one significant QTL on chromosomes (Chrs.) 9 and 6, respectively, whereas for protoscolex development, two suggestive and one highly significant QTLs were detected on Chrs. 6, 17 and 1, respectively. Our QTL analyses using murine AE models revealed that multiple genetic factors regulated host susceptibility/resistance to E. multilocularis infection. Moreover, our findings show that establishment of the parasite cysts in the liver is affected by QTLs that are distinct from those associated with the subsequent protoscolex development of the parasite, indicating that different host factors are involved in the host–parasite interplay at each developmental stage of the larval parasite. Further identification of responsible genes located on the identified QTLs could lead to the development of effective disease prevention and control strategies, including an intensive screening and clinical follow-up of genetically high-risk groups for AE infection. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/51381 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
