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Clinical impact of cycling the administration of antibiotics for febrile neutropenia in Japanese patients with hematological malignancy

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Title: Clinical impact of cycling the administration of antibiotics for febrile neutropenia in Japanese patients with hematological malignancy
Authors: Hashino, Satoshi Browse this author →KAKEN DB
Morita, Lena Browse this author
Kanamori, Hiroe Browse this author
Takahata, Mutsumi Browse this author
Onozawa, Masahiro Browse this author →KAKEN DB
Nakagawa, Masao Browse this author
Kawamura, Takahito Browse this author
Fujisawa, Fumie Browse this author
Kahata, Kaoru Browse this author
Izumiyama, Koh Browse this author
Yonezumi, Masakatsu Browse this author
Chiba, Koji Browse this author
Kondo, Takeshi Browse this author →KAKEN DB
Asaka, Masahiro Browse this author →KAKEN DB
Keywords: cycling antibiotics
febrile neutropenia
hematological malignancy
hematopoietic stem cell transplantation
Issue Date: Feb-2012
Publisher: Springer-Verlag
Journal Title: European Journal of Clinical Microbiology & Infectious Diseases
Volume: 31
Issue: 2
Start Page: 173
End Page: 178
Publisher DOI: 10.1007/s10096-011-1290-2
PMID: 21594713
Abstract: Despite the availability of newer classes of antibiotics, infection with multi-drug-resistant bacteria is a serious problem. To suppress the appearance of multi-drug-resistant bacteria and to avoid severe infection derived from febrile neutropenia (FN), we conducted cycling administration of antibiotics for FN in patients with hematological malignancy. The treatment protocol consisted of the administration of four antibiotics each for three months in one year. The above regimen was repeated for 4 years. A total of 193 patients were registered in the protocol. Mean duration of administration of cycling antibiotics was 5.9 days (range: 1-16 days). Frequency of FN before the study and during the study was unchanged until the third year but decreased significantly in the fourth year. Frequency of detection of multi-drug-resistant bacteria in the first year was the same as that before the study was started but dramatically decreased after the second year. Bacteriological treatment success rates were similar in each trimester and each year. Effective rate was not statistically different in each trimester and each year. We conclude that cycling administration of antibiotics in patients with FN is useful for suppressing the appearance of multi-drug-resistant bacteria and for obtaining excellent clinical efficacy.
Rights: The original publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/51747
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 橋野 聡

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